What is it?
Scutellaria baicalensis is used in traditional medicine to treat many medical conditions, but studies in humans are limited.
S. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine. It is often used in combination with other herbs.
Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Larger studies in humans that test safety and effectiveness are needed to determine under what circumstances S. baicalensis may be beneficial.
What are the potential uses and benefits?
- To treat cancer
Extracts from this herb cause cell death in some cancer cell lines, but human data are lacking. S. baicalensis has not been studied in clinical trials as a single agent, but has been studied in combination with other herbs in formulations such as PC-SPES and sho-saiko-to. - To treat arthritis
An herbal supplement containing S. baicalensis appeared to reduce symptoms of osteoarthritis. However, it is not known if the herb would exert similar effects by itself, and some supplements containing it have been associated with liver toxicity. - To treat hepatitis
The herbal formulation sho-saiko-to, which contains Huang Qin, has been studied for its possible liver-protectant effects.
What are the side effects?
- Liver damage
- Lung inflammation due to bacterial or viral infection
- Elevated high-sensitivity C-reactive protein and high triglycerides
Case Reports
Acute liver injury: In patients with arthritis, following consumption of a formula containing baicalin derived from S. baicalensis or Chinese skullcap.
What else do I need to know?
Do Not Take if:
- You are taking warfarin or other blood thinners: Lab studies suggest Chinese skullcap has similar effects and therefore, may increase bruising and bleeding risks. Clinical relevance has yet to be determined.
- You are taking statins: In healthy volunteers, Chinese skullcap decreased blood levels of drugs used to lower cholesterol.
- You are taking CYP450 substrate drugs: Lab studies suggest Chinese skullcap may increase the risk of side effects with these drugs. Clinical relevance has yet to be determined.