A Phase 3 Study Assessing the Addition of Tivozanib to Pembrolizumab Immunotherapy After Surgery for Kidney Cancer

Full Title

Short TeRm Intensified Pembrolizumab (KEytruda) and Tivozanib for High-Risk Renal Cell Carcinoma - STRIKE (A032201) (CIRB)

Purpose

Researchers want to see how well tivozanib plus pembrolizumab works in people with kidney cancer. The people in this study had surgery for renal cell carcinoma and have a high risk of it coming back.

Tivozanib blocks the action of an abnormal protein that tells tumor cells to multiply. This helps stop tumor cell spread. It is taken orally (by mouth).

Pembrolizumab works by helping the immune system attack cancer and inhibiting the growth and spread of tumor cells. It is given intravenously (by vein).

Giving pembrolizumab and tivozanib together may work better than pembrolizumab alone to treat renal cell cancer. If you take part in this study, you will be randomly assigned to get pembrolizumab alone or with tivozanib.

Contact

For more information and to see if you can join this study, please call Dr. Darren Feldman’s office at 646-888-4740.

Protocol
25-181
Phase
Phase III (phase 3)
Investigator
Co-Investigators
ClinicalTrials.gov ID
NCT06661720