Colin Malone

Colin Malone, PhD

Areas of Expertise

My Specialties

  • Cancer genomics
  • Molecular diagnostics
  • Precision medicine

Get to Know Me

I am the Scientific Director of Clinical Next-Generation Sequencing (NGS) at Memorial Sloan Kettering Cancer Center (MSK) within the Department of Pathology and Laboratory Medicine.

I focus on developing and running advanced DNA tests that allow doctors to understand a patient’s cancer and choose the most effective treatment. This approach is known as precision medicine.

I oversee the full lifecycle of clinical NGS testing, from preparing a patient’s sample and sequencing its DNA, to using smart technology to keep operations running efficiently. I also partner with medical directors, data scientists, and leadership to advance MSK’s clinical genomics strategy.

Our work builds on landmark platforms including MSK-IMPACT, MSK-ACCESS, and MSK-TARGET, which together have supported the genomic profiling of more than 100,000 MSK patients. The goal is simple: by understanding a tumor’s DNA we can find better ways to fight it.

What I Do at MSK

I'm a molecular geneticist at MSK. A molecular geneticist has special training in studying genes to research and diagnose diseases and disorders.

  • Scientific Director of Clinical Next-Generation Sequencing (NGS)
Areas of Expertise

My Specialties

  • Cancer genomics
  • Molecular diagnostics
  • Precision medicine
This list shows some key areas of focus, but it may not cover all expertise. When making an appointment, you will be matched with the best healthcare provider for your needs.
Education & Honors

Education

  • School of Biological Sciences, Cold Spring Harbor Laboratory, New York

Fellowships

  • Post-Doctoral Fellowship, Skirball Institute, New York University

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Learn more about the insurance plans that participate with MSK.

If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

Health plans can change at any time. Call the number on the back of your insurance card to see what your plan covers. Make sure it covers the MSK location where you’ll get care.

If you have questions about insurance, call us at 646-497-9176.

Contact and Location

Location
New York, NY

Looking to see a doctor at a different location? See all MSK locations.

Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

See all Clinical Computational Diagnostics Service doctors

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Clinical Trials

Smiling doctors in the lab
Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Search clinical trials

Research and Publications

Malone CD, Brennecke J, Dus M, Stark A, McCombie WR, Sachidanandam R, Hannon GJ. Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell. 2009 May 1;137(3):522-35. doi: 10.1016/j.cell.2009.03.040. Epub 2009 Apr 23. PMID: 19395010; PMCID: PMC2882632.

Malone CD, Mestdagh C, Akhtar J, Kreim N, Deinhard P, Sachidanandam R, Treisman J, Roignant JY. The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript. Genes Dev. 2014 Aug 15;28(16):1786-99. doi: 10.1101/gad.245829.114. Epub 2014 Aug 7. PMID: 25104425; PMCID: PMC4197963.

Malone CD, Hannon GJ. Small RNAs as guardians of the genome. Cell. 2009 Feb 20;136(4):656-68. doi: 10.1016/j.cell.2009.01.045. PMID: 19239887; PMCID: PMC2792755.

Publications on PubMed

Visit PubMed for a full listing of Dr. Malone’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Colin Malone discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2025 through disclosure submission in spring 2026). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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