David L. Wuest, MD


Chief, Blood Bank, Donor Room

David L. Wuest
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About Me

I am a board-certified pathologist and a specialist in blood-banking and tranfusion medicine. As Chief of Memorial Sloan Kettering’s Blood Bank and Donor Room, the foccus of my expertise is the collection of blood from donors, the processing and distribution of blood and blood-components, and the transfusion of blood and blood components to patients.

My clinical interests encompass the spectrum of transfusion medicine, starting from the management and testing of the blood we collect in order to ensure that we have a safe and adequate blood supply to meet the needs of our patients. Since blood supplies are limited, expensive, and carry some risks for recipients, we actively review all requests for transfusion to prevent unnecessary transfusions, and we continually evaluate guidelines for transfusion practice to determine if we can lower the number of patients who receive prophylactic transfusions.

The practice of transfusion medicine has become increasingly complex over the past decades as cancer treatments and those for related diseases have intensified and escalated. Patients undergoing transfusion can develop conditions including cytopenias (a reduction in one or more critical blood components), immunosuppression, graft-versus-host disease (GvHD), and infections. These have all increased the demand for transfusion therapy to support and treat patients with these complications and have increased the need for specially treated blood components (which are irradiated, leukocyte-reduced, and cytomegalovirus [CMV]-seronegative).

Memorial Sloan Kettering’s Donor Room provides a full range of services: We collect, process, and test standard blood components prepared from donations of both whole blood and particular blood components (obtained through a process called apheresis) from volunteer, autologous (self), or directed (intended for a specific patient) donors. We perform therapeutic apheresis, including photopheresis (in which blood is treated with drugs that are activated when exposed to ultraviolet light) to treat a variety of conditions, as well as cytapheresis (in which specific cell-based components are removed from the blood) to collect cellular components for autologous and allogeneic hematopoietic transplantation.

  • Clinical Expertise: Transfusion Medicine; Stem Cell Lab Processing
  • Languages Spoken: English
  • Education: MD, Ohio State University College of Medicine
  • Residencies: SUNY Downstate Medical Center; The New York Hospital-Cornell Medical Center
  • Fellowships: Cedars-Sinai Medical Center (Los Angeles)
  • Board Certifications: Anatomic and Clinical Pathology; Blood Banking and Transfusion Medicine


Visit PubMed for a full listing of David L. Wuest’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicare and New York State Medicaid also provide benefits for care at MSK.

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