I am a board-certified oncologist and hematologist, and work as part of a multidisciplinary team caring for patients with hematologic disorders. I have a special interest and expertise in treating patients with disorders that arise in white blood cells called plasma cells, including multiple myeloma and light chain (AL) amyloidosis.
My research focuses on new treatment approaches for plasma cell disorders. Along with colleagues here, I am testing targeted therapies, immunomodulatory agents, and stem cell transplantation to arrive at more-effective and less-toxic regimens for these diseases.
Very effective novel agents have recently become available for plasma cell disorders, but it is not clear if these are more effective than stem cell transplantation for patients early in the course of their disease. To help answer that question, I am co-leading a study comparing the effectiveness of an immunomodulatory agent (lenalidomide) with that of high-dose therapy and stem cell transplantation. I am also leading a trial to determine the most effective post-stem cell transplant therapy. As the principal investigator of an ongoing trial using a risk-adapted approach to stem cell transplant followed by novel agents in AL amyloidosis, I have had the opportunity to present exciting results demonstrating significant activity and low toxicity with this approach.
For patients whose plasma cell disorder has relapsed, I am investigating novel agents alone and in combinations. Some patients with multiple myeloma and plasma cell disorders do poorly despite treatment. I am collaborating with colleagues here in efforts to develop safer and more-effective donor-derived (allogeneic) hematopoietic stem cell transplantation options using T-cell-depleted grafts, a strategy pioneered at Memorial Sloan Kettering. In order to improve accessibility to treatment and the quality of life of our patients, I am also helping to develop outpatient transplant strategies using state-of-the-art technology (Tele-Health monitoring).
I have also enjoyed mentoring students from the college level through the post-graduate level.
- Clinical Expertise: Hematologic Malignancies with a focus on plasma cell dyscrasias including multiple myeloma, light chain amyloidosis, and plasmacytomas.
- Languages Spoken: English
- Education: MD, SUNY Upstate Medical University
- Residencies: University of Colorado Health Sciences Center
- Fellowships: Memorial Sloan Kettering Cancer Center; NewYork-Presbyterian Hospital/Weill Cornell Medical Center
- Board Certifications: Internal Medicine; Medical Oncology; Hematology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Heather J. Landau
- A Phase I Study of Carfilzomib in Patients with Previously Treated Systemic Light Chain Amyloidosis
- A Phase I Study of NEOD001 in Patients with Light Chain Amyloidosis
- A Phase I/IIA Study of Carfilzomib plus High-Dose Melphalan Before Autologous Stem Cell Transplant in Patients with Multiple Myeloma
- A Phase II Study of Bendamustine and Dexamethasone in Patients with Relapsed Amyloidosis
- A Phase III Study of Dexamethasone plus Ixazomib (MLN9708) or Standard Therapy in Patients with Recurrent or Persistent Systemic Light Chain Amyloidosis
Clinical Trials Co-Investigated by Heather J. Landau
- A Phase II Study of Bortezomib/Dexamethasone Followed by Lenalidomide in Nonresponders as Initial Treatment for Multiple Myeloma
- A Phase II Study of Lenalidomide and Low-Dose Dexamethasone (LD) Followed by Continued LD or Stem Cell Transplantation in Patients with Newly Diagnosed Multiple Myeloma
- A Phase III Study of Lenalidomide, Bortezomib, and Dexamethasone Combination Treatment with or without Peripheral Stem Cell Transplantation in the Initial Management of Multiple Myeloma
- A Pilot Study of Bortezomib/Dexamethasone Followed by Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone for the Initial Treatment of MIDD Associated with Multiple Myeloma and Amyloidosis