I am a pediatric oncologist who specializes in the care of children with neuroblastoma and other cancers that have spread in the central nervous system (the brain and spinal cord). I am conducting translational research to better understand why this happens and to try to find more-effective treatments, particularly for relapsed disease.
In my research, I am investigating novel treatments to eliminate microscopic tumor cells in the central nervous system. These novel treatments include monoclonal antibodies attached to radioactive substances (radioimmunotherapy) that are administered directly into the cerebrospinal fluid. We remain one of the few programs in the world committed to the cure of cancers of the leptomeninges.
The use of targeted radioimmunotherapy holds promise because it could reduce our reliance on external-beam radiation therapy to the brain, which can cause developmental delays in some young children. We are exploring new ways to target tumor cells while sparing the central nervous system and the rest of the body from the side effects of radiation.
I am active in teaching residents who are rotating through our service, and have had the special opportunity to mentor several fellows and medical students. I am honored to be part of a subspecialized team of healthcare professionals in Memorial Sloan Kettering’s Department of Pediatrics — including researchers, nurses, nurse practitioners, social workers, and research assistants — who are committed to improving the outcome for our patients.
I am also motivated by the inspirational parents of these patients, who are dedicated to driving legislation that supports funding for and awareness of these cancers. They, too, are vital members of our team. Our ultimate goal is to see our patients come back to see us years from now, doing well and thriving.
- Clinical Expertise: Pediatric Oncology; Neuroblastoma; Medulloblastoma; Neuroectodermal Tumors; Immunotherapy
- Awards and Honors: New York Magazine Top Doctors (2012-2016)
- Languages Spoken: English
- Education: MD, State University of New York Health Science Center at Syracuse
- Residencies: Strong Memorial Hospital (Rochester, New York)
- Fellowships: Memorial Sloan Kettering Cancer Center
- Board Certifications: Pediatrics; Pediatric Hematology-Oncology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Kim Kramer
- A Phase I Study of Intrathecal Radioimmunotherapy Using 131I-8H9 for Central Nervous System/Leptomeningeal Cancers
- A Phase I Study of Panobinostat in Children with Diffuse Intrinsic Pontine Glioma
- A Phase II Study of Intrathecal I131-3F8 in Patients with GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms
Clinical Trials Co-Investigated by Kim Kramer
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