Mark M. Souweidane, MD

About Me

I have dedicated my career to the surgical treatment of children with brain and spinal disorders. I am internationally recognized for my surgical experience in specific procedures, including the removal of intraventricular brain tumors, the management of pineal region tumors, the surgical removal of spinal tumors, the treatment of congenital cysts, and surgery for Chiari malformation.

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I specialize in minimally invasive “endoscopic” surgery for the treatment of hydrocephalus, intraventricular brain tumors, colloid cysts, and congenital cysts. This approach has revolutionized the way we treat these diseases, reducing the risk of complications and enhancing recovery with the same effectiveness as conventional open cranial procedures. In addition to children, I also use this approach to treat some adult patients.

I have an active laboratory that focuses on improving the outcome of children with brain tumors by studying brain tumor modeling and innovative approaches to administering chemotherapy.

Our research on the use of microscopic catheters to deliver therapeutic compounds in surgically inaccessible locations, known as convection-enhanced delivery, has paved the way for clinical studies and the possibility for effective treatments for children who otherwise do not have these options.

For example, in a phase 1 clinical trial that I am leading in children with diffuse intrinsic pontine glioma (DIPG), a type of brain stem glioma, we will evaluate the effectiveness and safety of delivering different dose levels of a novel therapeutic agent called 124I-8H9 directly into the tumor through convection-enhanced delivery. Find out more about this clinical trial and eligibility for enrollment by calling 212-639-2336.

In addition to my role as a neurosurgeon at Memorial Sloan Kettering, I serve as Vice Chairman of the Department of Neurological Surgery, Director of Pediatric Neurological Surgery, and Professor of Neurological Surgery and Pediatrics at Weill Cornell Medical College. Nationally, I am Chair of the Neurosurgery Committee of the Children’s Oncology Group, and I serve on the editorial boards of several of the most prominent peer-reviewed neurosurgery journals.

I am inspired by the children I treat and the commitment of their parents. When I meet a patient for the first time, I try to gain a level of trust, confidence, and comfort. I recognize that honesty, integrity, and humility are important components of my relationship with my patients and their parents, and these virtues form the foundation of everything I do.

  • Clinical Expertise: Pediatric Neurosurgery; Pediatric Brain Tumors; Neuroendoscopy; Intraventricular and Pineal Region Tumors
  • Languages Spoken: English
  • Education: MD, Wayne State University School of Medicine
  • Residencies: NYU Medical Center; University of Michigan Medical Center
  • Fellowships: The Hospital for Sick Children (Toronto)

New Patient Appointments

Making an appointment

Call 212-639-7056


Visit PubMed for a full listing of Mark M. Souweidane’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.


Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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