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The Lai laboratory integrates genetics, biochemistry, and genomewide approaches to study diverse regulatory networks during patterning and behavior.
The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.
Computational biologist Quaid Morris uses artificial intelligence techniques and develops machine learning algorithms to study gene regulation, cancer evolution, clinical informatics, and other topics in systems biology.
Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.
The laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets.
Molecular geneticist Britta Weigelt studies the genomics of gynecologic cancers and the use of circulating cell-free DNA for disease monitoring and the identification of therapy resistance mechanisms.
Immunologist Morgan Huse studies the structure and function of immune cell-cell interactions.
Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.
Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.
The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data.