The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumor-associated antigens. The Caov-3 cells harbor a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and adriamycin. These cells fail to grow in soft agar but are tumorigenic when injected into immunocompromised mice.
This cell line was established from the primary tumor of a 54-year-old Caucasian female with adenocarcinoma of the ovary.
Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
- Buick RN et al. (1985) Comparative properties of five human ovarian adenocarcinoma cell lines. Cancer Research 45: 3668-3676 (PubMed ID: 4016745)
- Yaginuma Y et al. (1992) Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Research 52: 4196-4199 (PubMed ID: 1638534)
- Shayesteh L et al. (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nature Genetics 21: 99 - 102 (PubMed ID: 9916799)
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