SK-MM-1 is a multiple myeloma cell line that grows in suspension culture. These cells display plasmacytoid morphology and have a doubling time of approximately 32 hours. SK-MM-1 cells do not express the Epstein-Barr virus nuclear antigen. These cells express the pan-B-cell marker B1 and the late B-cell/plasma cell marker BL3, but do not express any T-lymphocyte, myeloid, or early B-lymphocyte markers. SK-MM-1 cells secrete kappa light chains, but do not secrete any heavy chains.
This cell line was established in 1981 from immature plasma cells in the bone marrow of a 51 year-old male, of unknown ethnicity, with plasma cell leukemia.
Alan N. Houghton, MD, Attending Physician, Department of Medicine, Memorial Hospital; and Member, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Eton O et al. (1989) Establishment and characterization of two human myeloma cell lines secreting kappa light chains. Leukemia 3: 729-735 (PubMed ID: 2506399)
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