Description  

MDA231-BrM2-831 is a breast adenocarcinoma cell line established from the MDA231-TGL cell line after 2 passage in nude mice. It is a triple negative breast cancer (TNBC) cell line and a brain-selective metastatic derivative.  

This cell line is part of a panel of human breast cancer cell lines selected to metastasize to specific organs.    

Source 

Joan Massagué, PhD, Chief Scientific Officer, Director, Sloan Kettering Institute, and Laboratory Head, Cancer Biology & Genetics Program, MSK 

This cell line was established from a 51-year-old female of Caucasian ethnicity and was derived from a metastatic site of pleural effusion.   

Lead Inventor 

This cell line is jointly owned with MD Anderson and is available for licensing through an interinstitutional agreement. 

Key References 

• Minn A et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050) 518-524. (PubMed ID: 16049480) 

• Boire A et al. (2017) Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.Cell, 168(6), 1101-1113.e13. (PubMed ID: 28283064) 

Cellosaurus code:  

• RRID: CVCL_VR36