SK-UT-1B: Human Uterine Leiomyosarcoma Cell Line

SK-UT-1B: Human Uterine Leiomyosarcoma Cell Line

Description

SK-UT-1B is a subline of the SK-UT-1 human uterine leiomyosarcoma cell line and grows in adherent culture. Although the SK-UT-1B cell line forms tumors when inoculated in immunocompromised mice, the resulting tumors are different from tumors produced by the parental SK-UT-1 cell line. This cell line displays relatively low chromosome instability, compared to other established cancer cell lines.  SK-UT-1B maintains a near-diploid karyotype and is characterized by a very low percentage of polyploid cells. The SK-UT-1B cells have high levels of phosphorylated retinoblastoma protein, compared to the parental SK-UT-1 cells.

Source

This is a subline of the SK-UT-1 cell line.  The parental cell line was established in 1972 from a 75-year-old Caucasian female with a uterine mixed mesodermal tumor consistent with leiomyosarcoma  grade III.

Inventors

  • Lloyd J. Old, MD, former  William E. Snee Chair in Cancer Immunology, Memorial Sloan Kettering; former Director, New York Branch, Ludwig Institute for Cancer Research
  • Germaine Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering

Key References

  •   Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
  •  Chen TR (1988) SK-UT-1B, a human tumorigenic diploid cell line. Cancer Genetics and Cytogenetics 33: 77-81 (PubMed ID: 3383166)
  •    Mao X et al. (2008) Subtle genomic alterations and genomic instability revealed in diploid cancer cell lines. Cancer Letters 267: 49-54 (PubMed ID: 18407410)

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes.

Contact Information

  • For licensing requests: Alexandra Buga, MBA, Business Development Analyst, Office of Technology Development, MSK, 646-888-1078, bugaa@mskcc.org
  • For non-licensing requests from academic-research institutions: Frances Weis-Garcia, PhD, Associate Laboratory Member/Head, Antibody & Bioresource Core Facility, MSK, 646-888-2354, weisgarf@mskcc.org

Stage of Development

Ready to use

Indications