SK-UT-1B is a subline of the SK-UT-1 human uterine leiomyosarcoma cell line and grows in adherent culture. Although the SK-UT-1B cell line forms tumors when inoculated in immunocompromised mice, the resulting tumors are different from tumors produced by the parental SK-UT-1 cell line. This cell line displays relatively low chromosome instability, compared to other established cancer cell lines. SK-UT-1B maintains a near-diploid karyotype and is characterized by a very low percentage of polyploid cells. The SK-UT-1B cells have high levels of phosphorylated retinoblastoma protein, compared to the parental SK-UT-1 cells.
This is a subline of the SK-UT-1 cell line. The parental cell line was established in 1972 from a 75-year-old Caucasian female with a uterine mixed mesodermal tumor consistent with leiomyosarcoma grade III.
- Lloyd J. Old, MD, former William E. Snee Chair in Cancer Immunology, Memorial Sloan Kettering; former Director, New York Branch, Ludwig Institute for Cancer Research
- Germaine Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
- Chen TR (1988) SK-UT-1B, a human tumorigenic diploid cell line. Cancer Genetics and Cytogenetics 33: 77-81 (PubMed ID: 3383166)
- Mao X et al. (2008) Subtle genomic alterations and genomic instability revealed in diploid cancer cell lines. Cancer Letters 267: 49-54 (PubMed ID: 18407410)
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