Exosomes are 30–150 nm nanovesicles of endosomal origin that mediate intercellular communication in normal physiology and pathology. Tumor-derived exosome proteins or extracellular vesical and particles (EVPs) have prognostic and functional importance in tumor progression, immune regulation, and metastasis. Working collaboratively with the David Lyden Laboratory at Cornell, we examine the role of tumor-associated exosomes in lung adenocarcinoma (LUAD) and their ability to influence the tumor microenvironment and the biology of metastases. We recently opened a prospective clinical trial examining EVPs in patients with clinicopathologic-annotated LUAD before and after surgical resection of their primary tumor using blood, cancer, and normal tissue with a specific interest in exosomal proteomics, miRMA, and DNA. We believe this project will allow us to better understand the role of EVPs in the biology of lung cancer metastases, as well as potentially using EVPs as a biomarker for tumor aggressiveness and response to treatment.