Memorial Hospital Research Laboratories

The David Jones Lab

Research

David R. Jones, MD
David R. Jones, MD

The primary reason people die from cancer is the development of metastatic disease. As a surgeon-scientist who cares for patients with earlier stage lung and esophageal cancer, my laboratory studies why patients with completely resected cancer still develop metastases and die. We focus on a class of genes known as metastasis suppressor genes and, in particular, breast cancer metastasis suppressor I (BRMS1). We have identified important functions of BRMS1 as a transcriptional repressor, an E3 ligase, and a mediator of RelA/p65 transcription in lung cancer. We investigate BRMS1-mediated suppression of metastases in p53mut lung adenocarcinoma (LUAD), as well as the identification of a novel germline point mutation of BRMS1 variant 2, a pro-metastatic variant. Currently, we are exploring the role of the tumor immune microenvironment in BRMS1-loss tumors. Our lab is also examining tumor genomics in early stage LUAD and has built a comprehensive clinically- and genomically-annotated database. Our recent focus is LUAD organotropism, or the preferential metastasis to specific organ sites, and we have identified specific mutations that drive site-specific metastasis of LUAD. Over the past several years, we have established a large patient-derived organoid (PDO) program to explore the biology of metastases and related therapies in vitro and in novel mouse models of metastases.  Finally, we have initiated a prospective study examining the role of tumor-related exosomes and extravesical particles in the development of metastases in operable lung cancer patients. Collectively, the goal of my laboratory is to understand the biology of metastases in early-stage lung and esophageal cancer and develop therapies to mitigate this deadly process.

Research Projects

Lab Members

Publications Highlights

Lengel HB, Mastrogiacomo B, Connolly JG, Tan KS, Liu Y, Fick CN, Dunne EG, He D, Lankadasari MB, Satravada BA, Sun Y, Kundra R, Fong C, Smith S, Riely GJ, Rudin CM, Gomez DR, Solit DB, Berger MF, Li BT, Mayo MW, Matei I, Lyden DC, Adusumilli PS, Schultz N, Sanchez-Vega F, Jones DR. Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer Cell. 2023 May 8;41(5):970-985.e3.

Liu Y, Chudgar N, Mastrogiacomo B, He D, Lankadasari MB, Bapat S, Jones GD, Sanchez-Vega F, Tan KS, Schultz N, Mukherjee S, Offit K, Bao Y, Bott MJ, Rekhtman N, Adusumilli PS, Li BT, Mayo MW, Jones DR. A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos. Sci Transl Med. 2022;14(665):eabo1050.

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People

David R. Jones, MD

David R. Jones, MD

  • Physician-scientist David R. Jones studies molecular mechanisms governing the development of metastases in lung and esophageal cancers.
[email protected]
Email Address
212-639-6428
Office Phone
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Physician profile

Members

Tetsuhiko Asao

Research Fellow

Harsha Choudhary

Research Fellow

Lissa Dunne
Lissa Dunne

Research Fellow

Cameron Fick
Cameron Fick

Research Fellow

Manendra Lankadasari
Manendra Lankadasari

Research Fellow

Yuan Liu
Yuan Liu

Associate Attending Biochemistry

Brooke Mastrogiacomo
Brooke Mastrogiacomo

Computational Biologist Il

Lab Alumni
Elianna Amin

Research Scholar

Samhita Bapat
Samhita Bapat

Research Assistant

Whitney Brandt

Research Fellow

Peter Bucciarelli

Research Fellow

Raul Caso
Raul Caso

Research Fellow

Neel Chudgar

Research Fellow

Jake Connolly

Research Fellow

Di He
Di He

Research Fellow

Gregory Jones
Gregory Jones

Research Fellow

Harry Lengel
Harry Lengel

Research Fellow

Shi Yan
Shi Yan

Visiting Investigator

Jian Zhou
Jian Zhou

Visiting Investigator

Juan Zhou
Juan Zhou

Research Scholar

Lab Affiliations

Achievements

  • President, American Association for Thoracic Surgery 2024-2025
  • AACR Career Development Award for Translational Research in Lung Cancer 2001
  • Member, Tumor Progression and Metastases Study Section NCI; 2010-16 (Chair 2014-16)
  • Co-Director, Fiona and Stanley Druckenmiller Center for Lung Cancer Research, MSKCC
  • Castle Connolly Top Doctors for Cancer 2010-present

Open Positions

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

David R. Jones discloses the following relationships and financial interests:

  • AstraZeneca
    Professional Services and Activities
  • Dava Oncology
    Professional Services and Activities
  • MORE Health, Inc
    Professional Services and Activities
  • Merck & Co Inc.
    Professional Services and Activities (Uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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