Memorial Hospital Research Laboratories

The Luc Morris Lab

Research

Luc Morris
Luc Morris, MD, MSc, FACS

Our laboratory works at the intersection of cancer genomics, molecular biology, animal models, and patient clinical data, to better understand how the genetic features of cancer cells lead to tumor development, evasion of the immune system, and aggressive tumor behavior. This multi-faceted approach can help us to discover new biomarkers and new genetic drivers. Our group has focused for many years on cancers of the head and neck (especially squamous cell, salivary and thyroid cancers). Using this approach, we have identified new cancer genes, developed new animal models, uncovered factors that cancers use to resist therapy or escape immune surveillance, and critically assessed genetic biomarkers that predict response to immunotherapy across multiple cancer types. Through these efforts, we hope to deepen our understanding of cancer genetics, and help set the stage for the next steps of rational clinical investigation informed by molecular insights.

Morris Lab Figures

Publications

Valero C, Lee M, Hoen D, Weiss K, Kelly DW, Adusumilli PS, Paik PK, Plitas G, Ladanyi M, Postow MA, Ariyan CE, Shoushtari AN, Balachandran VP, Hakimi AA, Crago AM, Long Roche KC, Smith JJ, Ganly I, Wong RJ, Patel SG, Shah JP, Lee NY, Riaz N, Wang J, Zehir A, Berger MF, Chan TA, Seshan VE, Morris LG. Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors. Nature Communications 2021 [ePub]

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People

Luc Morris

Luc Morris, MD, MSc, FACS

  • Luc Morris is a physician-scientist whose laboratory studies how tumor genetics influence the development of cancer, escape from immune surveillance, and immunotherapy outcomes in cancers of the head and neck and other sites.
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Physician profile

Members

Xinzhu Deng, MD, PhD
Xinzhu Deng

Senior Research Scientist

James Cevallos

Graduate Student

Conall Fitzgerald

Research Fellow

Doug Hoen
Doug Hoen

Bioinformatics Engineer III

Fengshen Kuo

Bioinformatics Engineer III

Mark Lee

Medical Student

Cristina Valero Mayor

Research Fellow

Zaineb Nadeem
Zaineb Nadeem

Lab Manager

Neal Patel

Clinical Research Coordinator

Jingming Wang
Jingming Wang

Research Scholar

Lab Affiliations

Open Positions

Postdoctoral Fellow

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