Memorial Hospital Research Laboratories

The Luc Morris Lab


Luc Morris
Luc Morris, MD, MSc, FACS

Our laboratory works at the intersection of cancer genomics, molecular biology, animal models, and patient clinical data, to better understand how the genetic features of cancer cells lead to tumor development, evasion of the immune system, and aggressive tumor behavior. This multi-faceted approach can help us to discover new biomarkers and new genetic drivers. Our group has focused for many years on cancers of the head and neck (especially squamous cell, salivary and thyroid cancers). Using this approach, we have identified new cancer genes, developed new animal models, uncovered factors that cancers use to resist therapy or escape immune surveillance, and critically assessed genetic biomarkers that predict response to immunotherapy across multiple cancer types. Through these efforts, we hope to deepen our understanding of cancer genetics, and help set the stage for the next steps of rational clinical investigation informed by molecular insights.

Morris Lab Figures


Valero C, Lee M, Hoen D, Weiss K, Kelly DW, Adusumilli PS, Paik PK, Plitas G, Ladanyi M, Postow MA, Ariyan CE, Shoushtari AN, Balachandran VP, Hakimi AA, Crago AM, Long Roche KC, Smith JJ, Ganly I, Wong RJ, Patel SG, Shah JP, Lee NY, Riaz N, Wang J, Zehir A, Berger MF, Chan TA, Seshan VE, Morris LG. Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors. Nature Communications 2021 [ePub]

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Luc Morris

Luc Morris, MD, MSc, FACS

  • Luc Morris is a physician-scientist whose laboratory studies how tumor genetics influence the development of cancer, escape from immune surveillance, and immunotherapy outcomes in cancers of the head and neck and other sites.
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Conall Fitzgerald

Research Fellow

Zaineb Nadeem
Zaineb Nadeem

Lab Manager

Neal Patel

Clinical Research Coordinator

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