Jun-ichi Nitadori

Visiting Investigator

Jun-ichi Nitadori

Visiting Investigator

Awards and Scholarships

National Cancer Center, Japan Visiting Research Scholarship

Current Employment

Assistant Professor, Thoracic Surgery, University of Tokyo Hospital, Tokyo, Japan

Publications

Manuscripts 

  • Kadota K, Nitadori J, Ujiie H, Woo KM, Sima CS, Travis WD, Jones DR, Adusumilli PS*. Prognostic Impact of Immune Microenvironment in Lung Squamous Cell Carcinoma: Tumor-Infiltrating CD10+ Neutrophil/CD20+ Lymphocyte Ratio as an Independent Prognostic Factor. J Thorac Oncol. 2015 (in press)
  • Kadota K, Nitadori JI, Rekhtman N, Jones DR, Adusumilli PS*, Travis WD. Reevaluation and Reclassification of Resected Lung Carcinomas Originally Diagnosed as Squamous Cell Carcinoma Using Immunohistochemical Analysis. Am J Surg Pathol. 2015 Apr 10. [Epub ahead of print] PMID: 25871623.
  • Ujiie H, Kadota K, Nitadori JI, Aerts JG, Woo KM, Sima CS, Travis WD, Jones DR, Krug LM, Adusumilli PS*. Tumoral and stromal immune microenvironment in epithelioid malignant pleural mesothelioma: tumoral il-7 receptor, tumor-infiltrating cd20+ lymphocytes, and their ratio to tumor-associated macrophages are independent predictors of survival. Oncoimmunology. 2015 Mar 19;4(6): e1009285. eCollection 2015 Jun. (PMC4485766) PMID: 26155428
  • Kadota K, Nitadori JI, Sima CS, Ujiie H, Rizk NP, Jones DR, Adusumilli PS*, Travis WD*. Tumor Spread Through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences Following Limited Resection for Small Stage I Lung Adenocarcinomas. J Thorac Oncol. 2015 May;10(5):806-14. PMID: 25629637; PMCID: PMC4500042.
  • Kadota K, Villena-Vargas J, Nitadori JI, Sima CS, Jones DR, Travis WD, Adusumilli PS*. Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. Ann Surg Oncol. 2015 Jan 22. [Epub ahead of print] PMID: 25608772.
  • Kadota K, Nitadori JI, Woo KM, Sima CS, Finley DJ, Rusch VW, Adusumilli PS, Travis WD. Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic Factors for Worse Outcomes. J Thorac Oncol. 2014 Aug;9(8):1126-39. PMID: 24942260.
  • Yeh YC, Nitadori JI, Kadota K, Yoshizawa A, Rekhtman N, Moreira AL, Sima CS, Rusch VW, Adusumilli PS, Travis WD. Using Frozen Section to Identify Histologic Patterns in Stage I Lung Adenocarcinoma ≤ 3 cm: Accuracy and Interobserver Agreement. Histopathology. 2015 Jun;66(7):922-38. PMID: 24889415.
  • Nitadori JI, Bograd AJ, Morales EA, Rizk NP, Dunphy MP, Sima CS, Rusch VW, Adusumilli PS. Preoperative Consolidation-to-Tumor Ratio and SUVmax Stratify the  Risk of Recurrence in Patients Undergoing Limited Resection for Lung Adenocarcinoma ≤2 cm. Ann Surg Oncol. 2013 Dec;20(13):4282-8. PMID: 23955584.
  • Nitadori J, Bograd AJ, Kadota K, Sima CS, Rizk NP, Morales EA, Rusch VW, Travis WD, Adusumilli PS. Impact of Micropapillary Histologic Subtype in Selecting Limited Resection vs Lobectomy for Lung Adenocarcinoma of 2cm or Smaller. J Natl Cancer Inst. 2013 Aug 21;105(16):1212-20. PMID: 23926067; PMCID: PMC3748005.
  • Nitadori J, Colovos C, Kadota K, Sima CS, Sarkaria I, Rizk N, Rusch VW, Travis WD, Adusumilli PS. Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival among Patients with Lung Adenocarcinoma ≤2 cm: A Proposal to Reclassify T1 Lung Adenocarcinoma. Chest. 2013 Nov;144(5):1622-31. PMID: 23807749; PMCID: PMC3817930.
  • Kadota K, Nitadori J, Adusumilli PS. Prognostic immune microenvironment in lung adenocarcinoma. Oncoimmunology. 2013 May 1;2(5):e24036. PMID: 23762792; PMCID: PMC3667898.
  • Suzuki K, Kadota K, Sima CS, Nitadori J, Rusch VW, Travis W, Sadelain M, Adusumilli PS. Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor IL-12R & IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence. J Clin Oncol. 2013 Feb 1;31(4):490-8. PMID: 23269987; PMCID: PMC3731922.
  • Kadota K, Nitadori J, Sarkaria IS, Sima CS, Jia X, Yoshizawa A, Rusch VW, Travis WD, Adusumilli PS. Thyroid transcription factor–1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma. Cancer. 2013 Mar 1;119(5):931-8. PMID: 23096929; PMCID: PMC3691693.
  • Jain K, Bograd A, Nitadori J, Adusumilli PS. Why surgeons should fly. Natl Med J India. 2012 Jan-Feb;25(1):43-4. PMID: 22680324.
  • Kadota K, Kachala SS, Nitadori J, Suzuki K, Dunphy MPS, Sima CS, Travis WD, Rusch VW, Adusumilli PS. High-SUVmax on FDG-PET indicates pleomorphic subtype in epithelioid malignant pleural mesothelioma: supportive evidence to reclassify pleomorphic as non-epithelioid histology. J Thorac Oncol. 2012 Jul;7(7):1192-7. PMID: 22617244; PMCID: PMC3691682.
  • Servais EL, Colovos C, Rodriguez LA, Bograd AJ, Nitadori JI, Sima CS, Rusch VW, Sadelain M, Adusumilli PS. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res. 2012 May 1;18(9):2478-89. PMID: 22371455; PMCID: PMC3759995.

Abstracts/Presentations 

  • Kadota K, Nitadori JI, Sima CS, Jones DR, Travis WD, Adusumilli PS. Spread Through Alveolar Spaces: A Novel Pattern of Invasion Associated With Poor Prognosis in 411 Small ([le] 2cm) Stage I Lung Adenocarcinomas (LAdc).  United States & Canadian Academy of Pathology’s 104th Annual Meeting. March 21-27, 2015; Boston, MA.
  • Ujiie H, Buitrago D, Nitadori J, Kadota K, Krug L, Travis WD, Rusch VW, Sadelain M, Adusumilli PS. CD8 T-cell infiltration and tumor IL-7R expression are independent prognostic factors in epithelioid malignant pleural mesothelioma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Yeh YC, Nitadori J, Kadota K, Yoshizawa A, Rekhtman N,   Moreira A, Sima CS, Rusch VW, Adusumilli PS, Travis WD. Accuracy and interobserver agreement in identifying histologic subtypes in stage I lung adenocarcinoma ≤ 3 cm using frozen section. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Kadota K, Nitadori J, Finley D, Rusch VW, Adusumilli PS, Travis WD. Tumor budding and nuclear grade but not histologic subtyping are significant prognostic factors independent of TNM stage in patients with lung squamous cell carcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Kadota K, Nitadori J, Rusch VW, Rekhtman N, Sarkaria IS, Adusumilli PS, Travis WD. Reclassification of resected non-small cell lung carcinomas originally diagnosed as squamous cell carcinoma after reevaluation using immunohistochemistry (p40, p63, TTF-1, and Napsin A): Memorial Sloan-Kettering Cancer Center Experience. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Kadota K, Nitadori J, Cherkassky L, Rusch VW,  Travis WD, Sadelain M, Adusumilli PS. Prognostic impact of tumor-infiltrating immune cells in lung squamous cell carcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Villena-Vargas J, Kadota K, Nitadori J, Sima CS, Krug L, Travis WD, Rusch VW, Adusumilli PS. CD10 expression is an independent prognostic factor among all histological types of malignant pleural mesothelioma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Chen YC, Nitadori J, Kadota K, Sima CS, Rizk NP, Rusch VW, Travis WD, Adusumilli PS. Micropapillary histological subtyping is associated with occult lymph node metastasis (pN2) in clinically N2 negative (cN0/N1) stage I lung adenocarcinoma patients. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Nitadori J, Kadota K, Sima CS, Ujiie H, Rizk NP, Rusch VW, Travis WD, Adusumilli PS. Spread through alveolar spaces (STAS): A newly recognized pattern of invasion in lung adenocarcinoma associated with increased recurrence in patients undergoing limited resection for ≤2cm tumors. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Nitadori J, Colovos C, Kadota K, Sima CS, Rusch VW, Travis WD, Adusumilli PS. Visceral pleural invasion does not impact on recurrence-free or overall survival in lung adenocarcinoma ≤ 2 cm. Chicago Multidisciplinary Symposium in Thoracic Oncology, September 2012, Chicago, IL.
  • Servais EL, Colovos C, Rodriguez L, Bograd AJ, Nitadori J, Sima C, Sadelain M, Rusch VW, Adusumilli PS. Mesothelin promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in malignant pleural mesothelioma (MPM) patients: a potential mechanism for MPM regional aggressiveness. American Association for Thoracic Surgery 2012, Lillehei Forum, May 2012, San Francisco, CA.
  • Servais EL, Nitadori J, Morales EA, Suzuki K, Bograd AJ, Rizk NP, Downey RJ, Rusch VW, Adusumilli PS. Pre-operative consolidation to tumor ratio on computed tomography and FDG-PET SUVmax predict recurrence after limited resection of early lung adenocarcin-oma. American Association for Thoracic Surgery 2012, May 2012, San Francisco, CA.
  • Kadota K, Nitadori J, Suzuki K, Sima CS, Yoshizawa A, Rusch VW, Travis WD, Adusumilli PS. Thyroid transcription factor-1 expression correlates with predominant histologic subtypes and recurrence in stage I lung adenocarcinoma patients. United States and Canadian Academy of Pathology, March 17-23, 2012, Vancouver, Canada. Laboratory Investigation Feb2012;92(1):479A; Mod Pathol;25(2):479A
  • Yeh Y, Nitadori J, Kadota K, Yoshizawa A, Rusch VW, Adusumilli PS, Travis WD. Accuracy of frozen sections (FS) in predicting predominant histologic subtype and presence/absence of micropapillary and solid patterns in lung adenocarcinoma (ADC) ≤ 3 cm. United States and Canadian Academy of Pathology, March 17-23, 2012, Vancouver, Canada. Laboratory Investigation Feb2012;92(1):493A; Mod Pathol;25(2):493A
  • Nitadori J, Bograd AJ, Kadota K, Sima CS, Morales E, Suzuki K, Rizk NP, Rusch VW, Travis WD, Adusumilli PS. Micropapillary morphology is an independent predictor of recurrence in patients undergoing limited resection for lung adenocarcinoma (LAC) ≤2 cm. International Association for the Study of Lung Cancer (IASLC) 14th World Conference on Lung Cancer, July 2-5, 2011, Amsterdam, The Netherlands.