Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers.
We currently have a postdoctoral position available in the Adusumilli laboratory in the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center. The laboratory focus is in developing and translating adoptive T-cell therapy for the treatment of cancers.
Novel therapeutic perspectives in cancer immunotherapy have been developed with the introduction of genetic engineering technologies permitting efficient gene transfer in human primary T cells. Based on the use of recombinant oncoretroviruses and lentiviruses as vectors, we are investigating T-cell immunotherapy antitumor efficacy against various solid cancers including lung cancer, breast cancer, and mesothelioma. We have experience and have published on both immunodeficient and immunocompetent clinically relevant orthotopic mouse mode to characterize the tumor environment and the host immune system response to better understand and further develop cancer immunotherapy protocols. Our laboratory work has lead to two ongoing clinical trials, other trials are in planning.
Responsibilities include: working directly with the lab head to design, develop, and execute bench experiments; supervising technician/research fellow with bench experiments and coordinating with core laboratories to process samples; and data management. Additionally, he/she will analyze experimental results to derive logic conclusions, draft experimental procedures, prepare manuscripts pertaining to research work, and maintain detailed laboratory records.
Our ideal candidate will have a PhD or MD/PhD with a background in immunology and a passion for science and desire to impact cancer. Highly organized and self-directed individual with strong interpersonal skills and the ability to work in a dynamic environment is desired. Familiarity with general oncology and cancer pathogenesis, knowledge of molecular/genetic concepts, experimental methods, and data analysis, and ability to maximizing resources for troubleshooting pertaining to research activities are essential. Experience using mouse models, a willingness to do animal work and comfortable with handling of human blood and other tissues.