This work has led to convincing data showing that T-cells work efficiently when targeted to the tumor microenvironment. The strength of his research is the ability to noninvasively track, monitor, and measure pleural tumor burden and T-cell trafficking to better understand the biology of lung cancers and the efficacy of novel treatments.
Dr. Adusumilli’s goal is to transition his work toward advancing adoptive T-cell therapy via regional immune interventions and investigating this treatment in clinical trials.
Current areas of investigation include:
- Developing T-cell therapy for lung, breast, and mesothelioma cancers for translation to clinical trial
- Genetic strategies to enhance T-cell function and overcome solid tumor-mediated immunosuppression
- Noninvasive tumor and T-cell bioluminescent imaging to characterize trafficking of T-cell subsets
- Investigating the solid tumor microenvironment to identify novel cancer antigen targets for adoptive T-cell therapy
- Molecular characterization of lung adenocarcinoma morphological subtypes
Dr. Adusumilli trained as a research fellow at Memorial Sloan-Kettering and subsequently completed his thoracic surgery training at the University of Pittsburgh Medical Center. He then returned to Memorial Sloan-Kettering in 2007, specifically recruited to bolster the thoracic surgery translational research program within the Department of Surgery.
- Department of Defense (DoD) Breast Cancer Breakthrough Award
- Department of Defense (DoD) Technology/Therapeutic Development Award
- Department of Defense (DoD) Lung Cancer Promising Clinician Research Award
- National Cancer Institute R21 Award – Esophageal Adenocarcinoma
- National Cancer Institute R21 Award – Lung Adenocarcinoma
- AACR-AstraZeneca-Cancer Research and Prevention Foundation Fellowship in Translational Lung Cancer Research
- International Association for Study of Lung Cancer (IASLC) Lung Cancer Young Investigator Award
- National Lung Cancer Partnership Career Development Award
- American Association for Thoracic Surgery (AATS) Third Edward D. Churchill Research Scholarship
- Esophageal Cancer Education Foundation Research Grant
- Mesothelioma Applied Research Foundation’s Mesothelioma Research Grant Awards
- MSKCC’s Experimental Therapeutics Center (ETC) Drug Discovery and Development Award
- AACR Stand Up to Cancer and Cancer Research Institute Immunology Translational Research Dream Team