Prasad S. Adusumilli: Overview


This work has led to convincing data showing that T-cells work efficiently when targeted to the tumor microenvironment. The strength of his research is the ability to noninvasively track, monitor, and measure pleural tumor burden and T-cell trafficking to better understand the biology of lung cancers and the efficacy of novel treatments.

Dr. Adusumilli’s goal is to transition his work toward advancing adoptive T-cell therapy via regional immune interventions and investigating this treatment in clinical trials.

Current areas of investigation include:

  • Developing T-cell therapy for lung, breast, and mesothelioma cancers for translation to clinical trial
  • Genetic strategies to enhance T-cell function and overcome solid tumor-mediated immunosuppression
  • Noninvasive tumor and T-cell bioluminescent imaging to characterize trafficking of T-cell subsets
  • Investigating the solid tumor microenvironment to identify novel cancer antigen targets for adoptive T-cell therapy
  • Molecular characterization of lung adenocarcinoma morphological subtypes

Dr. Adusumilli trained as a research fellow at Memorial Sloan-Kettering and subsequently completed his thoracic surgery training at the University of Pittsburgh Medical Center. He then returned to Memorial Sloan-Kettering in 2007, specifically recruited to bolster the thoracic surgery translational research program within the Department of Surgery.

Laboratory Research Funding