Kyuichi Kadota

Senior Research Scientist

Kyuichi Kadota

Senior Research Scientist

Awards and Scholarships

Kagawa University Visiting Research Scholarship

Publications

Manuscripts

  • Kadota K, Eguchi T, Villena-Vargas J, Woo KM, Sima CS, Jones DR, Travis WD, Adusumilli PS. Nuclear Estrogen Receptor-α Expression Is an Independent Predictor of Recurrence in pT1aN0 Lung Adenocarcinomas, and Correlates with Regulatory T-Cell Infiltration. Oncotarget. 2015 (in press)
  • Ujiie H, Kadota K, Chaft JE, Buitrago DH, Sima CS, Lee MC, Huang J, Travis WD, Rizk NP, Rudin CM, Jones DR, Adusumilli PS. Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival. J Clin Oncol. 2015 (in press)
  • Kadota K, Nitadori J, Ujiie H, Woo KM, Sima CS, Travis WD, Jones DR, Adusumilli PS. Prognostic Impact of Immune Microenvironment in Lung Squamous Cell Carcinoma: Tumor-Infiltrating CD10+ Neutrophil/CD20+ Lymphocyte Ratio as an Independent Prognostic Factor. J Thorac Oncol. 2015 (in press)
  • Kadota K, Buitrago DH, Lee MC, Villena-Vargas J, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumoral CD10 Expression Correlates with High-Grade Histology and Increases Risk of Recurrence in Patients with Stage I Lung Adenocarcinoma. Lung Cancer. 2015 Jun 15. pii: S0169-5002(15)00288-3. PMID: 26141216; PMCID: PMC4156131.
  • Kadota K, Nitadori JI, Rekhtman N, Jones DR, Adusumilli PS, Travis WD. Reevaluation and Reclassification of Resected Lung Carcinomas Originally Diagnosed as Squamous Cell Carcinoma Using Immunohistochemical Analysis. Am J Surg Pathol. 2015 Apr 10. [Epub ahead of print] PMID: 25871623.
  • Kadota K, Yeh Y-C, Villena-Vargas J, Cherkassky L, Drill EN, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumor Budding Correlates with Protumor Immune Microenvironment and is an Independent Provgnostic Factor for Recurrence of Stage I Lung Adenocarcinoma. CHEST. 2015 Apr 2. [Epub ahead of print] PMID: 25836013.
  • Ujiie H, Kadota K, Nitadori JI, Aerts JG, Woo KM, Sima CS, Travis WD, Jones DR, Krug LM, Adusumilli PS. Tumoral and stromal immune microenvironment in epithelioid malignant pleural mesothelioma: tumoral il-7 receptor, tumor-infiltrating cd20+ lymphocytes, and their ratio to tumor-associated macrophages are independent predictors of survival. Oncoimmunology. 2015 Mar 19;4(6): e1009285. eCollection 2015 Jun. PMID: 26155428; PMCID: PMC4485766.
  • Buitrago DH, Patnaik SK, Kadota K, Kannisto E, Jones DR, Adusumilli PS. Small RNA sequencing for profiling microRNAs in long-term preserved formalin-fixed and paraffin-embedded non-small cell lung cancer tumor specimens. PLoS ONE. 2015 Mar 26;10(3):e0121521. eCollection 2015. PMID: 25812157; PMCID: PMC4374839.
  • Kadota K, Nitadori JI, Sima CS, Ujiie H, Rizk NP, Jones DR, Adusumilli PS, Travis WD. Tumor Spread Through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences Following Limited Resection for Small Stage I Lung Adenocarcinomas. J Thorac Oncol. 2015 May;10(5):806-14. PMID: 25629637; PMCID: PMC4500042.
  • Kadota K, Villena-Vargas J, Nitadori JI, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. Ann Surg Oncol. 2015 Jan 22. [Epub ahead of print] PMID: 25608772.
  • Eguchi T, Kadota K, Park BJ, Travis WD, Jones DR, Adusumilli PS. The IASLC/ATS/ERS Lung Adenocarcinoma Classification: what the surgeon should know. Semin Thorac Cardiovasc Surg. 2014 Autumn;26(3):210-22. PMID: 25527015; PMCID: PMC4272758.
  • Tozbikian G, Brogi E, Kadota K, Catalano J, Akram M, Patil S, Ho AY, Reis-Filho JS, Weigelt B, Norton L, Adusumilli PS, Wen HY. Mesothelin Expression in Triple Negative Breast Carcinomas Correlates Significantly with Basal-Like Phenotype, Distant Metastases and Decreased Survival. PLoS One. 2014 Dec 15;9(12):e114900. PMID: 25506917; PMCID: PMC4266616.
  • Liu Y, Mayo MW, Xiao A, Hall EH, Amin EB, Kadota K, Adusumilli PS, Jones DR. Loss of BRMS1 Promotes a Mesenchymal Phenotype through NF-κB-Dependent Regulation of Twist1. Mol Cell Biol. 2015 Jan;35(1):303-17. PMID: 25368381; PMCID: PMC4295387.
  • Lee MC, Buitrago DH, Kadota K, Ujiie H, Woo K, Sima CS, Travis WD, Jones DR, Adusumilli PS. The tumor immune microenvironment in octogenarians with stage I non-small cell lung cancer. Oncoimmunology. 2014 Nov 1;3(11):e967142. PMID: 25941595; PMCID: PMC4368147.
  • Lee MC, Kadota K, Buitrago DH, Jones DR, Adusumilli PS. Implementing the new IASLC/ATS/ERS classification of lung adenocarcinomas: results from international and Chinese cohorts. J Thorac Dis 2014 Oct;6(Suppl 5):S568-80. Review. PMID: 25349708; PMCID: PMC4209386.
  • Lee MC, Buitrago DH, Kadota K, Jones DR, Adusumilli PS. Recent advances and clinical implications of the micropapillary histological subtype in lung adenocarcinomas. Lung Cancer Manag. 2014 Jun 1;3(3):245-253. PMID: 25202339; PMCID: PMC4156131.
  • Kadota K, Yeh YC, D’Angelo SP, Moreira AL, Kuk D, Sima CS, Riely GJ, Arcila ME, Kris MG, Rusch VW, Adusumilli PS, Travis WD. Associations Between Mutations and Histologic Patterns of Mucin in Lung Adenocarcinoma: Invasive Mucinous Pattern and Extracellular Mucin Are Associated With KRAS Mutation. Am J Surg Pathol. 2014 Aug;38(8):1118-27. PMID: 25029118.
  • Kadota K, Nitadori JI, Woo KM, Sima CS, Finley DJ, Rusch VW, Adusumilli PS, Travis WD. Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic Factors for Worse Outcomes. J Thorac Oncol. 2014 Aug;9(8):1126-39. PMID: 24942260.
  • Yeh YC, Nitadori JI, Kadota K, Yoshizawa A, Rekhtman N, Moreira AL, Sima CS, Rusch VW, Adusumilli PS, Travis WD. Using Frozen Section to Identify Histologic Patterns in Stage I Lung Adenocarcinoma ≤ 3 cm: Accuracy and Interobserver Agreement. Histopathology. 2014 May 29. PMID: 24889415.
  • Kadota K, Villena-Vargas J, Yoshizawa A, Motoi N, Sima CS, Riely GJ, Rusch VW, Adusumilli PS, Travis WD. Prognostic Significance of Adenocarcinoma in situ, Minimally Invasive Adenocarcinoma, and Nonmucinous Lepidic Predominant Invasive Adenocarcinoma of the Lung in Patients with Stage I Disease. Am J Surg Pathol. 2014 Apr;38(4):448-60. PMID: 24472852; PMCID: PMC4164170.
  • Kachala SS, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, Chou J, Sima CS, Vertes E, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin  overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. Clin Cancer Res. 2014 Feb 15;20(4):1020-8. PMID: 24334761; PMCID: PMC3944669.
  • Kadota K, Yeh YC, Sima CS, Rusch VW, Moreira AL, Adusumilli PS, Travis WD. The Cribriform Pattern Identifies a Subset of Acinar Predominant Tumors with Poor Prognosis in Patients with Stage I Lung Adenocarcinoma: A Conceptual Proposal to Classify Cribriform Predominant Tumors as a Distinct Histologic Subtype. Mod Pathol. 2014 May;27(5):690-700. PMID: 24186133; PMCID: PMC4374572.
  • Nitadori J, Colovos C, Kadota K, Sima CS, Sarkaria I, Rizk N, Rusch VW, Travis WD, Adusumilli PS. Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival among Patients with Lung Adenocarcinoma ≤2 cm: A Proposal to Reclassify T1 Lung Adenocarcinoma. Chest. 2013 Nov;144(5):1622-31. PMID: 23807749; PMCID: PMC3817930.
  • Kadota K, Nitadori J, Adusumilli PS. Prognostic value of the immune microenvironment in lung adenocarcinoma. Oncoimmunology 2013;5: e24036-1-3. PMID 23762792; PMCID: PMC3667898.
  • Nitadori J, Bograd AJ, Kadota K, Sima CS, Rizk NP, Morales EA, Rusch VW, Travis WD, Adusumilli PS. Impact of micropapillary histologic subtype in selecting limited resection vs. lobectomy for lung adenocarcinoma ≤ 2 cm. J Natl Cancer Inst. 2013 Aug 21;105(16):1212-20. PMID: 23926067; PMCID: PMC3748005.
  • Suzuki K, Kadota K, Sima CS, Nitadori J, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence. J Clin Oncol. 2013 Feb
  • 1;31(4):490-8. PMID: 23269987; PMCID: PMC3731922.
  • Kadota K, Nitadori J, Sarkaria IS, Sima CS, Jia X, Yoshizawa A, Rusch VW, Travis WD, Adusumilli PS. Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma. Cancer. 2013 Mar 1;119(5):931-8. PMID: 23096929; PMCID: PMC3691693.
  • Kadota K, Colovos C, Suzuki K, Rizk NP, Dunphy MP, Zabor EC, Sima CS, Yoshizawa A, TravisWD, Rusch VW, Adusumilli PS. FDG-PET SUVmax Combined with IASLC/ATS/ERS Histologic Classification Improves the Prognostic Stratification of Patients with Stage I Lung Adenocarcinoma. Ann Surg Oncol. 2012 Oct;19(11):3598-605. PMID: 22644511; PMCID: PMC4049004.
  • Kadota K, Kachala SS, Nitadori J, Suzuki K, Dunphy MPS, Sima CS, Travis WD, Rusch VW, Adusumilli PS. High-SUVmax on FDG-PET indicates pleomorphic subtype in epithelioid malignant pleural mesothelioma: Supportive evidence to reclassify pleomorphic as non-epithelioid histology. J Thorac Oncol. 2012 Jul;7(7):1192-7. PMID: 22617244; PMCID: PMC3691682.
  • Kadota K, Suzuki K, Kachala SS, Zabor EC, Sima CS, Moreira AL, Yoshizawa A, Riely GJ, Rusch VW, Adusumilli PS, Travis WD. A grading system combining architectural features and mitotic count predicts recurrence in stage I lung adenocarcinoma. Mod Pathol. 2012 Aug;25(8):1117-27. PMID: 22499226; PMCID: PMC4382749.
  • Kadota K, Suzuki K, Colovos C, Sima CS, Rusch VW, Travis WD, Adusumilli PS. A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma. Mod Pathol. 2012 Feb;25(2):260-71. PMID: 21983936; PMCID: PMC4080411.
  • Suzuki K, Kadota K, Sima CS, Sadelain M, Rusch VW, Travis WD, Adusumilli PS. Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients. Cancer Immunol Immunother. 2011 Dec;60(12):1721-8. PMID: 21769693.
  • Suzuki K, Kachala SS, Kadota K, Shen R, Mo Q, Beer DG, Rusch VW, Travis WD, Adusumilli PS. Prognostic immune markers in non-small cell lung cancer. Clin Cancer Res. 2011 Aug 15;17(16):5247-56. Review. PMID: 21659461.
  • Kadota K, Suzuki K, Sima CS, Rusch VW, Adusumilli PS, Travis WD. Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma. J Thorac Oncol. 2011 May;6(5):896-904. PMID: 21358344.

Abstracts/Presentations

  • Tan KS, Kadota K, Moreira A, Adusumilli PS, Travis WD. Comparison of Grading Systems Based on Histologic Patterns and Mitotic Activity to Predict Recurrence in Stage I Lung Adenocarcinoma (ADC). International Association for the Study of Lung Cancer (IASLC) 16th World Conference on Lung Cancer. September 6-9, 2015; Denver, CO.
  • Kadota K, Nitadori JI, Sima CS, Jones DR, Travis WD, Adusumilli PS. Spread Through Alveolar Spaces: A Novel Pattern of Invasion Associated With Poor Prognosis in 411 Small ([le] 2cm) Stage I Lung Adenocarcinomas (LAdc).  United States & Canadian Academy of Pathology’s 104th Annual Meeting. March 21-27, 2015; Boston, MA.
  • Kadota K, Rekhtman N, Moreira AL, Arcila ME, Rusch VW, Adusumilli PS, Travis WD. Micropapillary Pattern and Invasive Tumor Size Are Prognostic Factors in Invasive Mucinous Adenocarcinoma of the Lung. United States & Canadian Academy of Pathology’s 103rd Annual Meeting, March 1-7, 2014, San Diego, CA. (Oral Presentation)
  • Kadota K, Arcila ME, Cyrus Hedvat, Kris MG, Rusch VW, Adusumilli PS, Travis WD. Poor prognostic driver mutations in early stage lung adenocarcinomas (LADs): BRAF and KRAS mutations for all LADs and KRAS mutations within the solid subtype alone. United States & Canadian Academy of Pathology’s 103rd Annual Meeting, March 1-7, 2014, San Diego, CA. (Oral Presentation)
  • Ujiie H, Buitrago D, Nitadori J, Kadota K, Krug L, Travis WD, Rusch VW, Sadelain M, Adusumilli PS. CD8 T-cell infiltration and tumor IL-7R expression are independent prognostic factors in epithelioid malignant pleural mesothelioma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Yeh YC, Nitadori J, Kadota K, Yoshizawa A, Rekhtman N,   Moreira A, Sima CS, Rusch VW, Adusumilli PS, Travis WD. Accuracy and interobserver agreement in identifying histologic subtypes in stage I lung adenocarcinoma ≤ 3 cm using frozen section. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Kadota K, Nitadori J, Finley D, Rusch VW, Adusumilli PS, Travis WD. Tumor budding and nuclear grade but not histologic subtyping are significant prognostic factors independent of TNM stage in patients with lung squamous cell carcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Ujiie H, Buitrago D, Kadota K, Huang J, Travis WD, Rusch VW, Adusumilli PS, Rizk NP. Sites, symptoms, CT scan findings and survival in patients with recurrence after curative-intent surgical resection for stage I lung adenocarcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Kadota K, Nitadori J, Rusch VW, Rekhtman N, Sarkaria IS, Adusumilli PS, Travis WD. Reclassification of resected non-small cell lung carcinomas originally diagnosed as squamous cell carcinoma after reevaluation using immunohistochemistry (p40, p63, TTF-1, and Napsin A): Memorial Sloan-Kettering Cancer Center Experience. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Kadota K, Yeh YC, Rizk NP, Rusch VW, Adusumilli PS, Travis WD. Tumor budding is a significant prognostic factor for recurrence independent of IASLC/ATS/ERS classification in patients with stage I lung adenocarcinoma, and correlates with protumor immune microenvironment. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Kadota K, Nitadori J, Cherkassky L, Rusch VW,  Travis WD, Sadelain M, Adusumilli PS. Prognostic impact of tumor-infiltrating immune cells in lung squamous cell carcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Lee MC, Kadota K, Ujiie H, Travis WD, Rusch VW, Sadelain M, Adusumilli PS. The Tumor immune microenvironment in octogenarians with stage I non-small cell lung cancer: Implications for immunotherapy. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Buitrago D, Kadota K, Rusch VW, Patnaik S, Adusumilli PS. MicroRNA profiling analysis in resectable formalin-fixed paraffin-embedded non small cell lung cancer specimens by microarray and next generation sequencing. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Villena-Vargas J, Kadota K, Nitadori J, Sima CS, Krug L, Travis WD, Rusch VW, Adusumilli PS. CD10 expression is an independent prognostic factor among all histological types of malignant pleural mesothelioma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Chen YC, Nitadori J, Kadota K, Sima CS, Rizk NP, Rusch VW, Travis WD, Adusumilli PS. Micropapillary histological subtyping is associated with occult lymph node metastasis (pN2) in clinically N2 negative (cN0/N1) stage I lung adenocarcinoma patients. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Nitadori J, Kadota K, Sima CS, Ujiie H, Rizk NP, Rusch VW, Travis WD, Adusumilli PS. Spread through alveolar spaces (STAS): A newly recognized pattern of invasion in lung adenocarcinoma associated with increased recurrence in patients undergoing limited resection for ≤2cm tumors. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Sima CS, Kadota K, Rusch VW, Travis WD, Adusumilli PS. Prognostic value and implications in reporting overall survival and incidence of recurrence in stage I lung adenocarcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Kadota K, Cherkassky L, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Nuclear estrogen receptor-α expression is a significant prognostic factor for recurrence, independent from the IASLC/ATS/ERS classification, in patients with pathologic stage T1aN0M0 disease, and correlates with poor prognostic immune microenvironment in lung adenocarcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Lee MC, Buitrago D, Kadota K, Sima CS, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Incremental association of solid histological subtype with predominant immunoinhibitory microenvironment in stage I lung adenocarcinoma (Tumor IL-7R and stromal FoxP3). International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)
  • Bograd A, Kadota K, Lee MC, Sarkaria IS, Rusch VW, Travis WD, Adusumilli PS. Tumoral neutral endopeptidase (CD10) expression predicts risk of recurrence, and further stratify intermediate-grade histology patients in stage I lung adenocarcinoma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia. (Oral Presentation)