The Precision Cellular Therapy Laboratory

Overview

Roni Shouval
Director

The Precision Cellular Therapy Laboratory is dedicated to advancing the understanding and effectiveness and safety of cellular therapies. Our research primarily focuses on uncovering drivers and mechanisms of resistance and toxicity that challenge the success of cellular therapies such as chimeric antigen receptor T-cell therapy and hematopoietic cell transplantation. By integrating multiomic approaches and novel computational techniques, we strive to identify and decode the biological drivers of disease resistance and adverse outcomes. Our goal is to translate these insights into more precise and safer therapeutic strategies, ultimately enhancing patient outcomes in hematologic malignancies and beyond.

Current Projects: 

  • Synthesizing multimodal data for prediction of CAR-T cell therapy outcome
  • Uncovering genomic drivers of resistance to CAR-T cell therapy in lymphoma
  • Dynamic Modeling of Cellular Therapy Toxicity
Shouval Lab Team Members

Publications

Atrial arrhythmias following CAR-chimeric antigen receptor T-cell therapy: Incidence, risk factors and biomarker profile. Shouval R, Goldman A, Flynn JR, El-Moghraby A, Rehman M, Devlin SM, Corona M, Landego I, Lin RJ, Scordo M, Raj SS, Giralt SA, Palomba ML, Dahi PB, Walji M, Salles G, Nath K, Geyer MB, Park JH, Fein JA, Kosmidou I, Shah GL, Liu JE, Perales MA, Mahmood SS.Br J Haematol. 2024 May 12. doi: 10.1111/bjh.19497. Online ahead of print.PMID: 38735683

Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma. Leithner D, Flynn JR, Devlin SM, Mauguen A, Fei T, Zeng S, Zheng J, Imber BS, Hubbeling H, Mayerhoefer ME, Bedmutha A, Luttwak E, Corona M, Dahi PB, Luna de Abia A, Landego I, Lin RJ, Palomba ML, Scordo M, Park JH, Tomas AA, Salles G, Lafontaine D, Michaud L, Shah GL, Perales MA, Shouval R*, Schöder H*. J Hematol Oncol. 2024 Apr 23;17(1):21. doi: 10.1186/s13045-024-01540-x. PMID: 38649972 Free PMC article. * Equal contribution

T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy. Storgard R, Rejeski K, Perales MA, Goldman A, Shouval R. JAMA Oncol. 2024 Apr 18. doi: 10.1001/jamaoncol.2024.0662. Online ahead of print. PMID: 38635228

Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity. Liang EC* Rejeski K*, Fei T, Albittar A, Huang JJ, Portuguese AJ, Wu Q, Raj S, Subklewe M, Shouval R*, Gauthier J*. Bone Marrow Transplant. 2024 Apr 16. doi: 10.1038/s41409-024-02278-3. Online ahead of print. PMID: 38627450 * Equal contribution

Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study. Youngster I, Eshel A, Geva M, Danylesko I, Henig I, Zuckerman T, Fried S, Yerushalmi R, Shem-Tov N, Fein JA, Bomze D, Shimoni A, Koren O, Shouval R*., Nagler A.* Bone Marrow Transplant. 2024 Mar;59(3):409-416. doi: 10.1038/s41409-024-02198-2. Epub 2024 Jan 11. PMID: 38212672 * Equal contribution

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People

Members

Mohammad Alhomoud

Assistant Attending

Magdalena Corona de Lapuerta

Visiting Investigator

Alfredo Rivas Delgado

Senior Research Scientist

Teng Fei

Assistant Attending Biostatistician

Cindy Junes

Administrative Assistant

Marina Gómez Llobell

Research Fellow

Danny Luan

Resident Researcher

Efrat Luttwak

Attending Physician and Clinical Investigator

Noriko Nishimura

Advanced Clinical Fellow

Sandeep Raj

Instructor, Adult BMT Service

Kai Rejeski

Research Fellow

Yannis Valtis

Oncology Fellow

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

General Opportunities

For inquiries about graduate student rotations, postdoctoral fellowships, medical research fellowships, or technician positions, please contact [email protected].

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