a powerful method for identifying where in the genome a protein of interest binds. It selectively enriches for genomic regions bound by a protein using its specific antibody. When coupled with next-generation sequencing, it can be used to determine genome-wide DNA binding sites of transcription factors and other chromatin-associated proteins.
Reference: Shang, Y., et al., Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell, 2000. 103(6): p. 843-52.