Request for Research Proposals
Eligible Applicants: Faculty ranked at Assistant Member Level I and above from Memorial Hospital or Sloan Kettering Institute
Issued: September 8, 2020
LOI Due Date: October 10, 2020
Grant funding from the Center for Epigenetics Research
The investigators of Memorial Sloan Kettering Cancer Center are invited to submit research applications for support from the Center for Epigenetics Research (CER). The goal of CER is to support highly creative and innovative research in epigenetics at MSKCC. CER will award support for projects that have the potential to lead to significant scientific breakthroughs in epigenetics research. As a highly flexible source of funding promoting feasibility studies and innovative collaborations, the CER Research Grants will be awarded on a competitive basis with support provided for up to two years, contingent on a satisfactory review of progress following the first year.
Two types of research projects will be funded:
- Pilot Project Grants (pre-RO1): Awards up to a total of $75,000. These awards will serve to provide seed money for pilot and feasibility studies, in which epigenetics is a main component, with the resulting data serving as a basis for grant applications to outside agencies.
- Project Collaborative Grants: Awards up to $200,000 per year for two years. These awards require the collaboration between at least two MSK laboratories. Successful proposals will use multidisciplinary approaches to obtain mechanistic insights into the role of epigenetic regulation in cellular processes, cell proliferation, differentiation, development and cancer.
Application Eligibility Requirements
- Faculty ranked at Assistant Member Level I and above from Memorial Hospital or Sloan Kettering Institute may submit applications for research support from the CER. Laboratory Track investigators are not eligible for CER funding.
- The scope of the proposals should have epigenetics research as a core component and it would include, but not be limited to, functional studies of chromatin-associated proteins and epigenetic pathways using model organisms, molecular or biochemical approaches, and bioinformatic analyses.
- Proposals should request funding for individual investigators. For the Project Collaborative Grants , the proposal should have at least two, but no more than three, teams with complementary scientific approaches. For these proposals, the LOI must describe the basis for synergy among the components of the team, and will be evaluated on that basis in addition to the scientific merit.
Direct budgets may be up to $75,000 for pilot projects, and up to $200,000/year for collaborative projects. All applicants must provide evidence that the proposed research is not already supported through other sources of funding. If a project with overlapping aims is being submitted to another grant opportunity then it is the PI’s responsibility to notify the CER Scientific Research Manager, Delphine Prou (firstname.lastname@example.org).
A one-page letter of intent (LOI) should be submitted and should include the project title, an outline of the specific aims of the proposal, the biosketches of individual investigator(s) and their programmatic/departmental affiliation(s), and an estimated budget amount for the duration of the grant (detailed budgets are not necessary). Please visit https://msk.infoready4.com/ to apply.
The letter must provide a rationale for the proposal, and describe the relevance of the proposal to the mission of CER. This is an important criterion for assessment of the LOI. Similarly, the integration and complementarity among components of collaborative projects will serve as criteria for the evaluation of LOIs for Collaborative Project awards.
After review, a fraction of the LOIs received will be selected for receipt of full proposals, which will be due by December 1st, 2020. Funding is expected to begin by February 2021.
Applicants may only submit one LOI as the principal investigator.
LOIs will be due by October 10, 2020 and should be submitted in INFOREADY.