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Physician-scientist Karlo Perica develops cell therapies to treat a wide variety of cancers, focusing on off-the-shelf approaches such as allogeneic CAR T cells and in vivo gene editing.

… The laboratory of Dr. Karlo Perica focuses on developing new Chimeric Antigen Receptor T cell and other cell therapies for cancer. We seek to make cell therapy more accessible and more effective by developing “off-the-shelf” approaches using allogeneic cell therapies and in vivo editing. Our research

Jonathan Coleman is a physician-scientist focused on translational research, cancer genomics, and patient-derived organoid models in the study of urologic malignancies. Ongoing work includes the development of local ablative therapies, their influence on the tumor microenvironment, and implications for therapy response.

… Our lab is focused on understanding the mechanism of disease recurrence, response to therapies and disease progression of upper tract urothelial cancer, a rare but aggressive disease. To interrogate molecular diversity of the disease, we employ genomics, transcriptomics, metabolomics and tumor immune

New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

… We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate

Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.

… Physician-scientist Charles M. Rudin, Chief of the Thoracic Oncology Service, leads research that focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models including patient-derived xenografts. These studies are integrated with early phase clinical trials

Immunologist Joseph Sun investigates the natural killer cell response against infection and cancer.

… The immune system responds to viral infections by introducing a complex interplay of immune cells and factors, whose goal is to eliminate the intruding pathogen. One such effector cell in the antiviral response is the Natural Killer (NK) cell, which secretes inflammatory cytokines and directly kills

Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.

… The human body is estimated to remove 1% of its body mass, likely more than 200 billion cells, every day. To achieve this, we rely on a highly evolutionarily conserved process: apoptotic cell clearance or ‘efferocytosis’. Efferocytosis is essential for normal development and tissue homeostasis, but also

Dr. Solomon is an interventional radiologist whose team investigates novel minimally invasive, image-guided therapies and their biologic and immunologic interactions.

… Our lab develops new minimally invasive image-guided cancer treatments: Methods for improving the anti-tumor immune response after embolization or ablation. Genetic, imaging, and other tests to predict response after embolization or ablation. New devices for endoluminal ablation (ureter, bile ducts,

The Gladkova lab studies the mechanisms and signals that reshape cellular organelle architecture in response to physiological stimuli.

… The Gladkova lab aims to uncover the principles that govern the shape, distribution and movement of organelles, with the ultimate goal of understanding how organelle architecture supports cellular function. This is essential, because defects in organelle maintenance cause neurodegeneration, and altered

Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involving human specimens processing, testing, and banking. For additional information on current research, publications, and presentations by the Lab, and more, scroll down and click on the ‘View Lab Overview’ or ‘Current Projects’ links.

…   The Molecular Epidemiology Laboratory Led by Dr. Irene Orlow, the Lab participates in self-initiated research and supports investigations from the Population Sciences & Clinical Research programs that involve handling and testing human specimens. For additional information on current research, publications