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The Tulpule lab studies how cells compartmentalize critical cellular processes with a focus on biomolecular condensates in cancer.

… The Tulpule Lab is interested in a long-standing question in cell biology: how do cells organize and compartmentalize critical cellular processes within the crowded and heterogeneous intracellular space? We focus on an emerging set of self-assembling, protein-based structures known as biomolecular condensates

Biomedical engineer Daniel Heller is Head of the Cancer Nanotechnology Laboratory, which invents disruptive technologies to revolutionize the diagnosis and treatment of cancer and allied diseases.

… Cancer Nanomedicine Laboratory We are a biomedical engineering laboratory that develops nanotechnologies to advance breakthroughs in the research, diagnosis, and treatment of cancer and allied diseases. We develop drug delivery technologies to target therapies to disease sites, advanced diagnostics to

We study mutational processes that drive cancer evolution and treatment resistance.

… The Lee Lab focuses on understanding how cancer genomes evolve under therapeutic pressure, with an emphasis on the origins, structure, and functional impact of genomic rearrangements. By integrating high throughput sequencing data from patient derived samples and experimental models, the lab develops

The Gitlin Lab studies the molecular and cellular mechanisms underlying inflammatory cell signaling in health and disease.

… The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with integrating diverse molecular signals from both host and pathogen to produce appropriately commensurate inflammatory

Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.

… Research efforts in the David lab apply core techniques in chemical biology, biochemistry, and cell biology to address fundamental questions in the epigenetic regulation of transcription. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

… The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.   Join the Powell Lab! Simon N. Powell, MD, PhD Enid A. Haupt Chair in Radiation Oncology Professor PhD, MD, University of London Email [email protected] Laboratory phone

Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.

… My laboratory studies the natural killer (NK) cell and the molecules that control its ability to recognize and kill cancer and virally infected cells. Improved understanding of how NK cells behave is critical to advancing our ability to harness their innate capacity for tumor recognition and eradication

… The Kung Lab leverages patient-driven discovery to identify drivers and therapeutic vulnerabilities in pediatric and young adult cancers. The research infrastructure of the lab bridges the clinic, dry lab, and wet lab, with experimental data derived from model systems as well as in-human studies. We

Computational biologist Christina Leslie focuses on developing machine learning algorithms for computational and systems biology.

… Our lab develops novel computational methods to study cellular biological systems from a global and data-driven perspective. We seek to exploit diverse, high-throughput functional and genomic data to understand the molecular networks underlying fundamental cellular processes, including regulation of

Physician-scientist Martin Weiser investigates the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.

… Our research investigates the natural history, molecular biology, and treatment response of cancers of the rectum and colon with the goal of personalizing therapy to reduce treatment toxicity, increase survival, and improve post-treatment quality of life.  We have built and tested clinical calculators