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Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.

… The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger

The Greenbaum lab utilizes techniques from statistical physics, information theory, and evolutionary biology to better understand the role of self/non-self discrimination in tumor evolution, model response to immunotherapies, and quantify drivers of virus and cancer evolution.

… A main goal in the Greenbaum lab is to quantify how the immune system is activated and how it impacts tumor evolution. A particular focus in the lab is the role of repetitive elements in the genome, which mimic viral features and, just like viruses, evolve to escape immune surveillance. Dr. Greenbaum

Cancer biologist Hans-Guido Wendel pursues both disease-centered and basic discovery research. The disease focus is on lymphocyte malignancies and the basic science arm of the lab explores fundamental mechanisms that control aberrant mRNA translation programs in cancer. Work in these two research areas frequently intersects in surprising ways.

… Our goal is to develop new cancer therapeutics and we are curious to identify biological vulnerabilities in cancer cells that provide opportunities for attack. Our research explores the molecular and cellular changes that drive cancer cells and ways to create new types of therapeutics including small

My research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes.

… Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann

The Hadjantonakis laboratory studies pluripotency and cell fate specification, tissue patterning and morphogenesis, in mammalian embryos and stem cell-derived embryo models.

… Cancer is a condition arising when cells undergo an identity crisis.  Understanding of how cells control their identity, and how they assemble into tissues with normal organization and function during embryonic development provides the essential blueprint for gaining insights into the fundamental biological

Cancer biologist Andrea Ventura studies non-coding RNAs in cancer and development

… One of the most exciting discoveries of the last two decades has been the identification of a large number of non-coding RNAs and the realization that they play essential roles in mammalian development and in diseases. Their study and the characterization of their contribution to the pathogenesis of

Computational biologist Ruslan Soldatov develops computational methods to study cell fate decisions and somatic evolution in normal tissues and cancer.

… The Soldatov Lab aims to characterize the mechanisms of cell fate decisions that coordinate tissue function and quantify how distortions of these mechanisms shape the course of cancer evolution. We are broadly interested in using a large-scale data science approach to study questions related to the organization

Optical engineer Milind Rajadhyaksha studies confocal microscopy for the imaging of cancer, technology development, and translational and clinical studies in skin and head and neck cancers.

… I am a mechanical and optical engineer and principal investigator in the Optical Imaging Laboratory in the Dermatology Service. My research focuses on creating novel confocal microscopes and endoscopes for imaging skin and head and neck cancers, and translating this technology to clinical applications

Molecular biologist Thomas Kelly studies regulatory mechanisms that control DNA replication during the cell cycle of eukaryotic cells.

… My long-term interest is to understand how the cellular genome is duplicated during the cell cycle. In the course of growth and division, eukaryotic cells duplicate their genomes with remarkable fidelity. The precision of this process depends in large measure upon stringent regulatory mechanisms that

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

… Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary