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The Diver lab studies the physiological roles and molecular mechanisms of understudied membrane-embedded proteins with the goal of revealing novel therapeutic targets for diseases such as pain and cancer.

… Most drugs target membrane proteins, accessible on the surface of cells, to alter the transport of ions and molecules and the transduction of cellular signals. The Diver lab explores the biological functions and molecular mechanisms of understudied transmembrane protein families with the goal of revealing

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.

… The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Marilyn Resh, PhD Member PhD, Harvard University AB, Princeton

The Functional MRI Laboratory provides pre-operative planning for patients with brain tumors and studies the clinical applications of advanced neuroimaging techniques for brain tumor imaging.

… Our lab utilizes functional, diffusion, and perfusion MRI to provide pre-operative planning for patients with brain tumors. The goal of our work is to identify key areas of the brain, such as areas for language, motor, sensory, and auditory function, prior to treatment so that neurosurgical interventions

The Greenbaum lab utilizes techniques from statistical physics, information theory, and evolutionary biology to better understand the role of self/non-self discrimination in tumor evolution, model response to immunotherapies, and quantify drivers of virus and cancer evolution.

… A main goal in the Greenbaum lab is to quantify how the immune system is activated and how it impacts tumor evolution. A particular focus in the lab is the role of repetitive elements in the genome, which mimic viral features and, just like viruses, evolve to escape immune surveillance. Dr. Greenbaum

The Lai laboratory integrates genetics, biochemistry, and genomewide approaches to study diverse regulatory networks during patterning and behavior.

… As a laboratory of developmental biology, our guiding interest is to comprehend how complex biological patterns can be assembled with stereotyped precision. This requires a detailed understanding of how cells come to execute appropriate behaviors — be it adoption of specific cell fates, proliferation

The Baylies laboratory studies the mechanisms that form and maintain muscle both during normal development and in disease.

… Developmental biologist Mary Baylies studies the mechanisms that form and maintain muscle both during normal development and in disease.   Mary Baylies, PhD Professor PhD, The Rockefeller University Achievements Identified that global, regional, and local inputs contribute to nuclear size regulation

Arvin Dar’s lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets.

… The Dar laboratory explores cancer mechanisms and new approaches in chemical biology. Our research integrates genetics, biochemistry, structure, and small molecule discovery. Our primary goal is to develop tools that enable us to modulate cell signaling networks, allowing for in-depth mechanistic exploration

Molecular geneticist Britta Weigelt studies the genomics of gynecologic cancers and the use of circulating cell-free DNA for disease monitoring and the identification of therapy resistance mechanisms.

… Gynecology DMT Research Laboratory Our laboratory focuses on the use of high-throughput genomics and functional genomics to identify drivers of rare gynecologic cancer types, and to define the clinical and biological significance of intra-tumor phenotypic and genetic heterogeneity in these tumors. Dr

The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.

… Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, regulation and catalysis. The ongoing major projects in the laboratory focus on the structural biology of CRISPR-Cas

Physician-scientist Michael Glickman investigates the physiology and pathogenic mechanisms of mycobacteria, including the use of mycobacteria as bacterial cancer therapies.

… We are broadly interested in the biology of mycobacteria,  including the major human pathogen M. tuberculosis , the nonpathogenic model organism M. smegmatis , and the cancer biotherapeutic agent BCG. Michael S. Glickman, MD Professor MD, Columbia University College of Physicians and Surgeons Email glickmam