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Molecular biologist Prasad Jallepalli studies the mechanisms that ensure accurate chromosome transmission in human cells.

… Our laboratory is interested in how human cells accurately duplicate and transmit their chromosomes during each round of division. Prasad Jallepalli, MD, PhD Member Professor MD, PhD, Johns Hopkins University School of Medicine Achievements Phi Beta Kappa, Harvard University (1992) M.D./Ph.D. Fellow,

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.

… The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches

The Brown Lab studies how the tissue environment shapes immune cell fate and function during early life immune development, inflammation, and cancer.

… At the Brown Lab, we’re studying how signals from the tissue environment shape the fate and function of immune cells and the mechanisms by which the immune system reciprocally regulates tissue homeostasis and host immunity. At the heart of an immune response are dendritic cells, sentinels of the immune

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

… The focus of the Fagin lab is to understand the pathogenesis and the biology of thyroid cancers at single cell resolution with the goal of identifying new mechanism-based therapies.  His group has been instrumental in characterizing somatic genetic changes associated with tumor initiation and progression

Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.

… The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design

Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.

… My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new

The Minn Lab investigates how cancers evolve under chronic inflammation and persistent immune pressure to acquire resistance to immunotherapies, with the goal of developing innovative therapies to restore anti-tumor immunity.

… In the Minn Lab, we interrogate the intersection of chronic inflammation and interferon signalling, virus mimicry pathways, and immune checkpoint resistance in tumor cells — integrating cellular, molecular and translational approaches. Our goal is to convert mechanistic insights into new therapeutic

Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.

… The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger

Researcher Michael Berger focuses on massively parallel sequencing of tumor DNA for biomarker discovery and clinical diagnostics.

… The focus of the Berger laboratory is to use novel computational and experimental techniques to characterize the spectrum of genetic mutations in human tumors in order to identify biomarkers of cancer progression and drug response. The identification of molecular drivers of cancer and the development

… About the Scott Lowe Lab Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically. Cancer arises through an