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The Lima laboratory studies mechanisms underlying RNA processing as well as post-translational protein modification by ubiquitin-like proteins.

… We are a research laboratory that studies fundamental structural, biochemical, and functional attributes for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation

The Lai laboratory integrates genetics, biochemistry, and genomewide approaches to study diverse regulatory networks during patterning and behavior.

… As a laboratory of developmental biology, our guiding interest is to comprehend how complex biological patterns can be assembled with stereotyped precision. This requires a detailed understanding of how cells come to execute appropriate behaviors — be it adoption of specific cell fates, proliferation

The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.

… Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, regulation and catalysis. The ongoing major projects in the laboratory focus on the structural biology of CRISPR-Cas

Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.

… The Luo Lab is interested in developing and leveraging novel approaches at the interface of chemistry and biology to annotate functional roles of epigenetic modulators. Epigenetic regulation is essential for maintaining cellular fates and its dysregulation has been associated with various diseases including

The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.

… Our mission is the development of a “new” generation of optical imaging technologies to enable advances in two hitherto difficult-to-investigate areas: the real-time analysis of macromolecular interactions and motions at the nanometer scale in vivo and the three-dimensional architecture of complex molecular

Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.

… We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

… Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in cancer. In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple

Arvin Dar’s lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets.

… The Dar laboratory explores cancer mechanisms and new approaches in chemical biology. Our research integrates genetics, biochemistry, structure, and small molecule discovery. Our primary goal is to develop tools that enable us to modulate cell signaling networks, allowing for in-depth mechanistic exploration

Computational biologist Christina Leslie focuses on developing machine learning algorithms for computational and systems biology.

… Our lab develops novel computational methods to study cellular biological systems from a global and data-driven perspective. We seek to exploit diverse, high-throughput functional and genomic data to understand the molecular networks underlying fundamental cellular processes, including regulation of

The Tulpule lab studies how cells compartmentalize critical cellular processes with a focus on biomolecular condensates in cancer.

… The Tulpule Lab is interested in a long-standing question in cell biology: how do cells organize and compartmentalize critical cellular processes within the crowded and heterogeneous intracellular space? We focus on an emerging set of self-assembling, protein-based structures known as biomolecular condensates