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Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

… Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges,

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

… Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

… Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance.  Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.

… The Boire lab studies leptomeningeal metastasis as a means to understand the principles of metastasis as well as the nervous system’s relationship to the larger organism. Adrienne A. Boire, MD, PhD Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center Associate Professor PhD

The Sheu-Gruttadauria Lab investigates how biomolecular condensates and biological phase transitions shape gene expression in physiology and disease.

… The Sheu-Gruttadauria Lab asks fundamental questions about how the cell organizes gene expression. We are particularly interested in biomolecular condensates, a class of membraneless cellular compartments that concentrate factors involved in nearly every step of RNA metabolism from transcription to decay

We develop and clinically deploy novel computational algorithms for analyzing multiscale, multimodal biomedical imaging data.

… The Nadeem Lab analyzes, interprets, and infers novel insights from biomedical data at multiple scales (macro: radiology/ surgery, meso: pathology, micro: genomics/ transcriptomics/ proteomics/ metabolomics) for improving patient outcomes. We use advanced mathematical and machine learning techniques

Physician-scientist Aimee Crago studies mechanisms by which common genomic events drive initiation and progression of soft tissue tumors.

… The rarity of soft tissue sarcomas has historically made the definition of genomic drivers of their initiation and progression difficult.  Through copy number, whole exome and transcriptome analyses, however, common events associated with these lesions have recently been defined.  The focus of our laboratory

Cell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.

… The research of my laboratory focuses on two directions highly relevant to cancer biology, (1) the molecular basis of programmed cell death processes (including apoptosis and ferroptosis), and their roles in human disease; and (2) the molecular basis of autophagy and its role in cancer. We also study

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.

… Research Interests Basic & Translational research in Cancer and Alzheimer’s disease: From disease mechanism to therapeutic development. Research Areas Target Identification & Drug Discovery Chemical Biology & Medicinal Chemistry Biochemistry & Enzymology Biophysics & Structural Biology Animal models

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

… Andrew Intlekofer is an Assistant Member in the Human Oncology and Pathogenesis Program and an Attending Physician on the Lymphoma Service in the Department of Medicine. Dr. Intlekofer’s research investigates how deregulated metabolic pathways contribute to cancer development and how metabolic enzymes