At any time Memorial Sloan Kettering Cancer Center is conducting hundreds of clinical trials to improve care for many types of cancer. Use the tool below to browse our clinical trials that are currently enrolling new patients. Each listing explains the purpose of the trial, the trial’s eligibility criteria, and how to get more information.
The list below includes clinical trials for adult cancers. Please visit our pediatric cancer care section to find a pediatric clinical trial.
Memorial Sloan Kettering offers language assistance services for those who prefer to receive health information in another language. Learn more about our language assistance program here.
- Improving Cord Blood Transplantation Outcomes for Adults With High-Risk Blood Cancers
Full Title Optimized Cord Blood Transplantation for the Treatment of High-Risk Hematologic Malignancies in Adults
Purpose
Umbilical card blood is rich in healthy, blood-forming cells (stem cells) that are very good at fighting blood cancers. Cord blood transplants (CBT) are a standard treatment for adults with blood cancers who lack a genetically matched stem cell donor. Cord blood is donated by a baby’s mother at birth. CBT uses stem cells from cord blood collections to replace cells that have been destroyed by disease or anti-cancer treatment.
Memorial Sloan Kettering Cancer Center (MSK) has developed a standard (“optimized”) practice for CBT using FDA-approved drugs. This optimized practice includes standards for:
- How patients are assessed as candidates for transplant
- The conditioning treatment (standard chemotherapy and total body radiation therapy) used to prepare for transplant
- The amount of stem cells transplanted
- How people are followed during and after CBT
- How patients are monitored for complications after CBT
The purpose of this study is to see if MSK’s optimized CBT practice is safer and more effective. The people in this study have blood cancers with a high risk of returning after treatment, including:
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Other acute leukemias
- Myelodysplastic syndromes
- Myeloproliferative disorders
- Non-Hodgkin lymphoma
- Blastic plasmacytoid dendritic cell neoplasm
Who Can Join
To join this study, there are a few conditions. You must:
- Have one of the blood cancers listed above, which has a high chance of coming back after treatment.
- Be recommended for a cord blood transplant.
- Have recovered from the serious side effect of previous therapies.
- Be age 21-65.
Contact
For more information about this study and to see if you can join, please call Dr. Ioannis Politikos’ office at 646-608-3773.
Protocol
23-143Phase
Phase II (phase 2)Disease Status
Relapsed or RefractoryInvestigator
Co-Investigators
Diseases
Locations
ClinicalTrials.gov ID
NCT05884333ClinicalTrials.gov
-
AZD5492 is called a T cell-engaging antibody. AZD5492 helps the immune system target and eliminate cancer cells.
-
Urothelial cancers can grow in different parts of the urinary tract. This includes the ureter (the tube that carries urine from the kidneys to the bladder) and renal pelvis. The renal pelvis is where the ureter connects to the kidneys. The standard treatment is surgery to remove the ureter, kidney, or both. In this study, researchers want to see if enfortumab vedotin, given before surgery, is useful for treating urothelial cancers. The people in this study have high-risk urothelial cancers of the upper urinary tract. High risk means there is a greater chance of the cancer coming back after treatment.
-
Researchers want to see if Tec-RVd after 3 treatment cycles of Dara-RVd is safe for people with multiple myeloma. The people in this study have newly diagnosed multiple myeloma.
-
The standard approach to controlling pain after mastectomy includes intravenous and oral pain-relieving medications. In this study, researchers are determining if adding a long-acting local anesthetic, bupivacaine, into the wound at the end of the operation is more effective at reducing pain than the standard medications alone for women having a mastectomy on one side with no immediate reconstruction afterward.
-
KIF5B/RET is an abnormal gene that leads to the growth of lung cancer cells. Cabozantinib inhibits the effects of this gene. In addition, this drug interferes with other pathways that also cause cancer cells to grow, form new blood vessels, and spread to other parts of the body.
-
Studies have shown that patients with newly diagnosed localized non-germinomatous germ cell tumors (NGGCT) of the brain or spinal cord whose disease responds well to chemotherapy before receiving radiation therapy are more likely to be free of the disease for a longer time than patients in whom chemotherapy is less effective.
-
Researchers are assessing a lower dose of standard radiation therapy after chemotherapy in young people with germinomas. The patients in this study have germinomas of the central nervous system (brain or spinal cord).  It is hoped that this new approach can destroy germinomas with fewer long-term side effects.
- A Phase 1/2 Study of CBL0137 to Treat Advanced Solid Tumors in Children and Young Adults
Full Title A Phase 1/2 Trial of CBL0137 (NSC# 825802, IND# 155843) in Patients with Relapsed or Refractory Solid Tumors including CNS Tumors and Lymphoma (PEPN2111) (CIRB)
Purpose
Researchers in this study are seeking the best dose of CBL0137 in people with solid tumors. They also want to see how well it works against certain cancers.
The best dose was already found in the first part of this study. The people in this study will now be limited to children and young adults with osteosarcoma or certain types of brain or brain stem tumors (gliomas). In addition, their cancers came back or keep growing even with treatment.
CBL0137 blocks signals between molecules inside a cell. Blocking these signals may kill cancer cells. CBL0137 is given intravenously (by vein).
Who Can Join
To join this study, there are a few conditions. You or your child must:
- Have osteosarcoma or a brain or brain stem glioma that keeps growing even with treatment.
- Have recovered from the serious side effects of prior therapies before getting CBL0137.
- Be able to walk and do routine activities for more than half the time you are awake.
- Be between the ages of 1 and 30 years.
Contact
For more information or to see if you or your child can join this study, please call 833-MSK-KIDS.
Protocol
23-215Phase
Phase I/II (phases 1 and 2 combined)Disease Status
Relapsed or RefractoryInvestigator
Co-Investigators
Diseases
Locations
ClinicalTrials.gov ID
NCT04870944ClinicalTrials.gov
-
Researchers want to see if elacestrant alone or with abemaciclib works well against endometrial cancer. The people in this study have endometrial cancer that has spread or come back. Their cancers have a protein called the estrogen receptor (ER) and they have a normal version of the p53 gene. This gene stops cancer from growing.