At any time Memorial Sloan Kettering Cancer Center is conducting hundreds of clinical trials to improve care for many types of cancer. Use the tool below to browse our clinical trials that are currently enrolling new patients. Each listing explains the purpose of the trial, the trial’s eligibility criteria, and how to get more information.
The list below includes clinical trials for adult cancers. Please visit our pediatric cancer care section to find a pediatric clinical trial.
Memorial Sloan Kettering offers language assistance services for those who prefer to receive health information in another language. Learn more about our language assistance program here.
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The purpose of this study is to assess the safety and effectiveness of treating rare advanced genitourinary cancers with the immunotherapies nivolumab and ipilimumab plus the drug cabozantinib.
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The purpose of this study is to compare the safety and effectiveness of personalized drug treatments that are given before surgery to remove stage I, II, or III non-small cell lung cancer (NSCLC) in patients whose tumors have certain genetic changes (mutations). Researchers believe these targeted therapies may effectively treat the tumor before surgery.
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Researchers are assessing two different doses of revumenib to give with azacitidine and venetoclax in young people with leukemia. This study includes children, teens, and young adults with acute myeloid leukemia (AML) or acute leukemia of ambiguous lineage (ALAL) that came back or keeps progressing after treatment.
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Researchers want to find the best dose of INCB161734 to use in people with advanced cancer. The people in this study have solid tumors that have spread. In addition, their cancers have a genetic mutation (change) called KRAS G12D.
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Researchers are comparing RMC-6236 with standard therapy in people with advanced pancreatic cancer. The people in this study have pancreatic cancer that has metastasized (spread) and keeps growing even after treatment.
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This purpose of this study is to assess two interventions to improve cancer care for older adults with cancer. Patients will be randomly assigned to one of the two interventions, which each consist of four surveys, five telephone sessions, and four subsequent "booster" calls with a licensed mental health counselor. The five telephone sessions each last about 45-60 minutes; the booster calls each last approximately 20-30 minutes. These surveys will include questions about each patient's illness, quality of life, depression, anxiety, and attitudes about aging and can be done via computer or over the phone. Patients will be compensated for their participation.
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In this study, researchers want to find the highest dose of the investigational drug ORIC-944 that can be given safely in people with metastatic prostate cancer that continues to grow despite standard treatments. ORIC-944 works by blocking a group of proteins called PRC2, which promote prostate cancer growth. It is taken orally (by mouth).
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To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
- A Phase 1-2 Study of ADCE-D01 in People With Advanced Soft Tissue Sarcoma
Full Title A First-in-human, Phase 1/2, Multicenter, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Antitumor activity of ADCE-D01, a Humanized Anti-human uPARAP Antibody Linked to a Topoisomerase I Inhibitor, in Patients with Metastatic and/or Unresectable Soft Tissue Sarcoma
Purpose
Researchers want to find the best dose of ADCE-D01 to treat soft tissue sarcoma. In this study, we treat people with soft tissue sarcoma that is inoperable (cannot be surgically removed) or metastasized (spread).
ADCE-D01 acts like a Trojan horse to kill sarcoma cells. It has two parts. One part sticks to certain proteins on cancer cells and enters the cells. Then the second part, an anti-cancer drug (poison), is released to kill them. ADCE-D01 is given intravenously (by vein).
Who Can Join
To join this study, there are a few conditions. You must:
- Have metastatic or inoperable soft tissue sarcoma that keeps growing after 1 or 2 prior types of chemotherapy.
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Have recovered from the side effects of previous treatments before getting ADCE-D01.
- Be well enough to walk and take care of yourself. You must be able to do activities such as office work or light housework to take part in the study.
- Be age 18 or older.
Contact
For more information or to see if you can join this study, please call Dr. Robert Maki’s office at 646-888-5059.
Protocol
25-031Phase
Phase I/II (phases 1 and 2 combined)Disease Status
Relapsed or RefractoryInvestigator
Co-Investigators
Diseases
Locations
ClinicalTrials.gov ID
NCT06797999ClinicalTrials.gov
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Researchers want to learn if giving ivosidenib with other drugs is safe and works well in people with advanced cholangiocarcinoma. The people in this study have cholangiocarcinoma that has metastasized (spread) and is inoperable (cannot be removed with surgery). Their tumors have a mutation (change) in the IDH1 gene.