I am a medical oncologist and a laboratory scientist. As a member of the Genitourinary Oncology Service, I specialize in treating cancers of the prostate, bladder, kidney, testis, and other related cancers. I treat my patients with chemotherapy, targeted therapies, immunotherapy, or combinations of these drugs, and I work with other cancer experts including surgeons and radiation oncologists to develop an individual treatment plan for each patient.
I am very involved in clinical trials, particularly those of targeted drugs known as kinase inhibitors, which block pathways inside cancer cells that cause the cells to grow or spread. One area of focus in my research is studying patients who are known as extraordinary responders. These are people with difficult-to-treat cancers who are found to respond exceptionally well to a new drug, even though that drug does not work in most people with the same disease.
My laboratory in the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering completed the first whole-genome analysis of a patient with bladder cancer. This patient had a complete and durable response to a novel targeted drug that was effective in only a small minority of patients. By performing this analysis, we were able to determine what was genetically unique about this patient’s tumor. We are now testing the same drug in other patients whose tumors have a similar genetic profile.
As the Director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology (CMO) at Memorial Sloan Kettering, I also lead a multidisciplinary team of clinicians, geneticists, bioinformaticians, and laboratory scientists. The mission of the CMO is to integrate molecular and clinical information to develop therapies that are individualized to each patient’s cancer.
My colleagues and I work to make sure that all patients who come to Memorial Sloan Kettering receive the best care possible, whether that means conventional or experimental therapies.
- Clinical Expertise: Genitourinary Oncology; Prostate Cancer
- Languages Spoken: English
- Education: MD, University of Pennsylvania School of Medicine
- Residencies: Internal Medicine - Barnes Jewish Hospital
- Fellowships: Medical Oncology/Hematology - Memorial Sloan Kettering Cancer Center; Medicine - Weill Cornell Medical College
- Board Certifications: Internal Medicine; Medical Oncology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Co-Investigated by David B. Solit
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