Santosha Vardhana, MD, PhD

About Me

I am a medical oncologist who specializes in treating and researching Hodgkin and non-Hodgkin lymphomas. I provide comprehensive care for people who have been admitted to Memorial Hospital, Memorial Sloan Kettering’s inpatient facility.

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My research is focused on how we can harness the body’s immune system to attack cancer. I am particularly interested in exploring how changes in metabolic pathways affect the immune system’s ability to recognize and eliminate cancer cells. As a scientist, I draw inspiration from the courage of my patients and their determination to better understand the disease they are facing and, ultimately, develop new strategies to help them.

Patients often have a great deal of anxiety about what their future holds. It can be difficult to imagine what life will be like when they leave the hospital. I hope to help my patients understand what to expect in both the short term and long term by clearly explaining their disease, how it occurs, and how we can treat it. I work closely with their outpatient doctors to ensure that we are approaching their treatment as a united front.

  • Clinical Expertise: Hodgkin lymphoma; Non-Hodgkin Lymphoma
  • Awards and Honors: Parker Fellow, Parker Institute for Cancer Immunotherapy (2017); Young Investigator Award, American Society of Clinical Oncology (2016); Fellowship in Clinical Lymphoma Research, American Association of Cancer Research (2016)
  • Languages Spoken: English
  • Education: PhD, New York University School of Medicine; MD, New York University School of Medicine
  • Residencies: Internal Medicine – NewYork-Presbyterian Hospital/Weill Cornell Medical Center
  • Fellowships: Medical Oncology – Memorial Sloan Kettering Cancer Center
  • Board Certifications: Internal Medicine; Medical Oncology

My Research

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See Santosha Vardhana’s laboratory
research at Memorial Sloan Kettering.

See My Colleagues


Vardhana S, Choudhuri K, Varma R, Dustin ML. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity. 2010 Apr 23;32(4):531-40.

Kumari S, Vardhana S, Cammer M, Curado S, Santos L, Sheetz MP, Dustin ML. T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol. 2012;3:230. Doi: 10.3389/fimmu.2012.00230.

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Vardhana S, Sauter CS, Matasar MJ, Zelenetz AD, Galasso N, Woo KM, Zhang Z, Moskowitz CH. Outcomes of primary refractory diffuse large B-cell lymphoma (DLBCL) treated with salvage chemotherapy and intention to transplant in the rituximab era. Br J Haematol. 2016 Dec 16.

Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML. Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol. 2010;28:79-105. Doi: 10.1146/annurev-immunol-030409-101308.

Vardhana S, Younes A. The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints. Haematologica. 2016 Jul; 101(7): 794-802.

Visit PubMed for a full listing of Santosha Vardhana’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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