Human Oncology & Pathogenesis Program

The Santosha Vardhana Lab

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Research

Santosha Vardhana
Santosha Vardhana, MD, PhD

The Vardhana lab explores how metabolites regulate immune cell homeostasis, particularly within tumors.  We use a combination of traditional immunology, synthetic biology, metabolomics, and bioinformatics to answer fundamental biological questions about the regulation of immune responses with the goal of applying these strategies broadly for the treatment of cancer.  Our team is made up of a diverse group of scientists and physicians with backgrounds in immunology, cancer biology, metabolism, and molecular genetics, but we are enthusiastic about integrating members with expertise across physical, life, and computer sciences to achieve our goal of taking novel experimental approaches to understand the complexity of host immunity.

Research Projects

The Santosha Vardhana Lab Group

Featured News

In the Lab
3D illustration of T cells surrounding a cancer cell.
Study Shows How Immune Cells Lose Their Power to Fight Tumors

Researchers discover why cancer immunotherapies often fail to finish the job.
Immune Status Could Determine Efficacy of COVID-19 Therapies

Emerging evidence suggests that SARS-CoV-2 can drive a diverse array of immune processes, raising the risk that immunosuppressant agents that are in cl...
In the Lab
Jedd Wolchok in his lab
The Many Faces of the Immune Response to COVID-19: How Cancer Research Is Contributing to a Deeper Understanding

During the COVID-19 pandemic, MSK doctors and researchers are applying their knowledge about immunology toward the development of treatments.

Publications

Vardhana S, Hwee M, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink M, Cross JR, Thompson CB. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T-cells exposed to persistent antigen. Nat Immunol 2020, July 13. Doi: 10.1038/s41590-020-0725-2.

Vardhana S, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019 Jul;1(7):676-687.

Vardhana S, Choudhuri K, Varma R, Dustin ML. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity. 2010 Apr 23;32(4):531-40.

Finley LW*, Vardhana S* (co-first author), Carey BW*, Koche R, Chen Y, Alonso-Curbelo D, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nat Cell Biol. 2018 May; 20(5): 565-574.

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People

Santosha Vardhana

Santosha Vardhana, MD, PhD

  • The Vardhana Lab studies how nutrient availability, uptake and metabolism regulates host immune responses during cancer development and immunotherapy.
  • PhD, New York University
[email protected]
Email Address
646-888-2703
Office Phone
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Physician profile

Members

Vanessa Brito
Vanessa Brito

Administrative Assistant

Yan-Ting (Kevin) Chen
Yan-Ting Chen

PhD Student

Katarina Liberatore
Katarina Liberatore

PhD Student

Ya-Hui Lin
Ya-Hui Lin

Senior Research Technician

Lisa McGary
Lisa McGary
Tiffany Merlinsky

PhD Student

Tanmana Mitra
Tanmana Mitra

Grad Student

Jahan Rahman
Jahan Rahman

Computational Biologist II

Joshua Schoenfeld
Joshua Schoenfeld

Research Fellow

Luis Somarribas Patterson
Luis Felipe Somarribas Patterson

Research Fellow

Lab Alumni
Madeline Hwee
Madeline Hwee

Research Technician

Lab Affiliations

Achievements

  • Chief Medical Oncology Fellow, Internal Medicine, Memorial Sloan Kettering Cancer Center (2014)
  • Young Investigator Award, American Society of Clinical Oncology (2016)
  • Senior Fellow, Parker Institute of Cancer Immunotherapy (2017)
  • Burroughs Wellcome Fund Career Award for Medical Scientists (2019)
  • MSKCC Award for Teaching Excellence (2019)
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Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

Our lab actively looking looking for new members.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Santosha Vardhana discloses the following relationships and financial interests:

  • ADC Therapeutics
    Provision of Services
  • Immunai Inc.
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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