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Scot Niglio

Scot Niglio, MD

Genitourinary Medical Oncologist

Areas of Expertise

Conditions I Treat

  • Genitourinary cancers and conditions
  • Gallbladder cancer
  • Kidney (renal cell) cancer and conditions

My Specialties

  • Clinical trials
  • Immunotherapy
  • Targeted therapy
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Dr. Niglio's Office Information
Languages: English
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Get to Know Me

I am a genitourinary medical oncologist who diagnoses and treats genitourinary cancers. This includes:


I specialize in urothelial carcinoma which are cancers that originate in the bladder, urethra, ureter, and renal pelvis. I also have extensive experience in treating rare genitourinary cancers.

I see patients at the David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center and at Memorial Sloan Kettering Westchester locations.

At Memorial Sloan Kettering Cancer Center (MSK), our team-based approach to treatment means each person’s cancer care is seen from numerous angles. We work closely with other specialists, including surgeons and radiation oncologists. When appropriate, we offer people the opportunity to participate in clinical trials.

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My interest in cancer care developed early. I grew up in a cancer cluster where a higher-than-expected rate of childhood cancer cases forced a temporary shutoff of water to area schools. Chemicals buried by a dye company years earlier may have leached into the town’s well water. Living through that experience motivated me to learn more about environmental protections and cancer research.

My father’s own bladder cancer diagnosis while I was in residency played a big role in my decision to specialize in genitourinary oncology. My personal experience taught me that communicating with patients and families during the entire process is a crucial part of providing seamless cancer care. People cannot be expected to remember everything in one sitting, so in the beginning, I break things up over multiple visits. I go over information multiple times, and I am happy to take questions that come up after people leave the office.

My research focus is to develop new treatments for these cancers which include immunotherapy. I have numerous articles in peer-reviewed publications, and I have been part of many clinical trials researching treatments for bladder and urinary tract cancers.

I received a National Institutes of Health Director’s Award for my work as part of the phase 1 team that developed an immunotherapy combination that is now approved by the U.S. Food and Drug Administration (FDA) as a first-line therapy for advanced kidney cancer.

What I Do at MSK

A genitourinary (jeh-nih-toh-YOOR-ih-nayr-ee) medical oncologist is a cancer doctor who specializes in genitourinary (GU) cancers. This includes bladder, kidney, penis, prostate, and testicular cancers.

  • Assistant Attending Physician
Areas of Expertise

Conditions I Treat

  • Genitourinary cancers and conditions
  • Gallbladder cancer
  • Kidney (renal cell) cancer and conditions
  • Testicular cancer
  • Prostate cancer and conditions

My Specialties

  • Clinical trials
  • Immunotherapy
  • Targeted therapy
Education & Honors

Education

  • BS in Biology, Villanova University
  • MS in Physiology, Georgetown University
  • MS in Clinical and Translational Science, University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences
  • MD, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School

Residencies

  • Internal Medicine, Icahn School of Medicine at Mount Sinai

Fellowships

  • Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai

Board Certifications

  • Internal Medicine
  • Medical Oncology

Awards and Honors

  • National Institutes of Health Director’s Award, National Institutes of Health (2021)
  • Young Investigator Award, Conquer Cancer Foundation (2019)
  • 40 under 40 in Cancer, Lynx Group (2019)

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Aetna

In Network Coverage Type
HMO, EPO PPO, POS, Transplant

Aetna Medicare Advantage (MTA and NYC retirees only)

In Network Coverage Type
PPO

Anthem BCBS and other BCBS licensee plans

In Network Coverage Type
PPO, POS, EPO, HMO

See updates

Anthem BCBS Health Plus

In Network Coverage Type
HMO

See updates

Blue Cross Blue Shield Federal Employee Program

In Network Coverage Type
HMO, PPO

See updates

Blue Cross Blue Shield states outside of NY/NJ

In Network Coverage Type
HMO, EPO PPO, POS

See updates

Carrum Health

In Network Coverage Type
Supplemental

Cigna

In Network Coverage Type
PPO, POS, HMO

Connecticare

In Network Coverage Type
POS, EPO, HMO

First Health

In Network Coverage Type
PPO

Straight NJ Medicaid

In Network Coverage Type
State Government

Straight NY Medicaid

In Network Coverage Type
State Government

Emblem

In Network Coverage Type
PPO, POS, EPO, HMO

Offers a qualified health plan from the Health Insurance Marketplace. Call Emblem to learn more.

Emblem Essential

In Network Coverage Type
HMO

Emblem Medicare Advantage (Medicare Choice PPO Network and VIP Prime Network Only)

In Network Coverage Type
PPO, HMO

Empire Essential

In Network Coverage Type
HMO

Empire Plan / NYSHIP (Blue Cross/UnitedHealthcare split plan)

In Network Coverage Type
PPO

See updates

Fidelis

In Network Coverage Type
HMO, EPO

Offers a qualified health plan from the Health Insurance Marketplace. Call Fidelis to learn more.

Fidelis Managed Medicaid & HARP

In Network Coverage Type
HMO

Fidelis Medicare Advantage

In Network Coverage Type
HMO

Healthfirst

In Network Coverage Type
EPO, HMO, PPO, POS

Offers a qualified health plan from the Health Insurance Marketplace. Call Healthfirst to learn more.

Healthfirst Managed Medicaid

In Network Coverage Type
HMO

Healthfirst Medicare Advantage

In Network Coverage Type
HMO, PPO

Healthsmart

In Network Coverage Type
PPO EPO

Horizon Blue Cross Blue Shield New Jersey (HMO)

In Network Coverage Type
HMO

See updates

Horizon Blue Cross Blue Shield New Jersey (PPO)

In Network Coverage Type
PPO

See updates

Horizon Blue Cross Blue Shield New Jersey Omnia Tier I (EPO)

In Network Coverage Type
EPO

See updates

Horizon Blue Cross Blue Shield New Jersey Omnia Tier II (EPO)

In Network Coverage Type
EPO

See updates

Horizon Medicare Advantage

In Network Coverage Type
PPO, HMO

Husky CT Medicaid

In Network Coverage Type
State Government

Magnacare

In Network Coverage Type
PPO, POS, EPO

Medicare Part A&B (traditional Medicare)

In Network Coverage Type
Federal Government

Metroplus

In Network Coverage Type
HMO

City Employee Health Plans (Gold and Gold Care)

Multiplan/Beech Street/PHCS

In Network Coverage Type
Supplemental

MVP

In Network Coverage Type
PPO/OAP

Non-Participating Plans with Out of Network Benefits

In Network Coverage Type
PPO, POS, EPO, HMO

NYC Medicare Advantage Plus for City Employees

In Network Coverage Type
TBD

Oscar

In Network Coverage Type
HMO/EPO

Oxford

In Network Coverage Type
PPO, EPO

World Trade Center Health Program (WTC)

In Network Coverage Type
State Government

Qualcare

In Network Coverage Type
PPO, POS, HMO

Tricare

In Network Coverage Type
PPO, HMO

UMR

In Network Coverage Type
PPO, POS

United Healthcare

In Network Coverage Type
PPO, POS, HMO

Don't see your carrier or plan? We can help you understand your coverage.

If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

If you have questions about insurance, call us at 646-497-9176.

Make an Appointment

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Current Patients
Request an appointment by logging in to MSK MyChart or calling your Care Team. If you are not enrolled in MSK MyChart, ask your Care Team to send you an invitation. You can also go to MSK MyChart and select “Sign up now.”

Contact and Location

Dr. Niglio sees patients at two locations.

Office Phone
Location
New York, NY
West Harrison, NY
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
530 East 74th Street New York NY 10021
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Memorial Sloan Kettering Westchester
500 Westchester Avenue West Harrison NY 10604
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Looking to see a doctor at a different location? See all MSK locations.

Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

See all Genitourinary Oncology Service doctors

Clinical Trials

Smiling doctors in the lab
Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Search clinical trials

Research and Publications

  1. Apolo AB, Ballman KV, Sonpavde G, Berg S, Kim WY, Parikh R, Teo MY, Sweis RF, Geynisman DM, Grivas P, Chatta G, Reichert ZR, Kim JW, Bilen MA, McGregor B, Singh P, Tripathi A, Cole S, Simon N, Niglio S, Ley L, Cordes L, Srinivas S, Huang J, Odegaard M, Watt C, Petrylak D, Hoffman-Censits J, Wen Y, Hahn O, Mitchell C, Tan A, Streicher H, Sharon E, Moon H, Woods M, Halabi S, Perez Burbano G, Morris MJ, Rosenberg JE. Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma. N Engl J Med. 2025 Jan 2;392(1):45-55. doi: 10.1056/NEJMoa2401726. Epub 2024 Sep 15. PMID: 39282902; PMCID: PMC11698643.
  2. Niglio SA, Purswani JM, Schiff PB, Lischalk JW, Huang WC, Murray KS, Apolo AB. Organ preservation in muscle-invasive urothelial bladder cancer. Curr Opin Oncol. 2024 May 1;36(3):155-163. doi: 10.1097/CCO.0000000000001038. Epub 2024 Mar 8. PMID: 38573204.
  3. Apolo AB, Girardi DM, Niglio SA, Nadal R, Kydd AR, Simon N, Ley L, Cordes LM, Chandran E, Steinberg SM, Lee S, Lee MJ, Rastogi S, Sato N, Cao L, Banday AR, Boudjadi S, Merino MJ, Toubaji A, Akbulut D, Redd B, Bagheri H, Costello R, Gurram S, Agarwal PK, Chalfin HJ, Valera V, Streicher H, Wright JJ, Sharon E, Figg WD, Parnes HL, Gulley JL, Saraiya B, Pal SK, Quinn D, Stein MN, Lara PN, Bottaro DP, Mortazavi A. Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors. J Clin Oncol. 2024 Sep 1;42(25):3033-3046. doi: 10.1200/JCO.23.02233. Epub 2024 Jul 2. PMID: 38954785; PMCID: PMC11361361.,
  4. Necchi A, Roumiguié M, Kamat AM, Shore ND, Boormans JL, Esen AA, Lebret T, Kandori S, Bajorin DF, Krieger LEM, Niglio SA, Uchio EM, Seo HK, de Wit R, Singer EA, Grivas P, Nishiyama H, Li H, Baranwal P, Van den Sigtenhorst-Fijlstra M, Kapadia E, Kulkarni GS. Pembrolizumab monotherapy for high-risk non-muscle-invasive bladder cancer without carcinoma in situ and unresponsive to BCG (KEYNOTE-057): a single-arm, multicentre, phase 2 trial. Lancet Oncol. 2024 Jun;25(6):720-730. doi: 10.1016/S1470-2045(24)00178-5. Epub 2024 May 10. PMID: 38740030.,
  5. Niglio SA, Jia R, Ji J, Ruder S, Patel VG, Martini A, Sfakianos JP, Marqueen KE, Waingankar N, Mehrazin R, Wiklund P, Oh WK, Mazumdar M, Ferket BS, Galsky MD. Programmed Death-1 or Programmed Death Ligand-1 Blockade in Patients with Platinum-resistant Metastatic Urothelial Cancer: A Systematic Review and Meta-analysis. Eur Urol. 2019 Dec;76(6):782-789. doi: 10.1016/j.eururo.2019.05.037. Epub 2019 Jun 11. PMID: 31200951.
Publications on PubMed

Visit PubMed for a full listing of Dr. Niglio’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed