I am a board-certified neurologist and clinical neurophysiologist. My clinical expertise includes examining the nervous system function using electrodiagnostic tests. My research interest is in diagnosis and management of neuromuscular disorders associated with cancer.
- Clinical Expertise: Clinical Neurophysiology; Neuromuscular Disorders
- Languages Spoken: English
- Education: MD, Fujian Medical College (Fujian, China); Master of Medicine, Tongji Medical University (Hubei, China); PhD, Shanghai Second Medical University (Shanghai, China)
- Residencies: St. John Episcopal Hospital (New York); NYU Medical Center
- Fellowships: NYU Medical Center; NewYork-Presbyterian Hospital/Columbia University Medical Center
- Board Certifications: Neurology; Clinical Neurophysiology
Ren Y, Xu HW, Davey F, Taylor M, Aiton J, Coote P, Fang F, Yao J, Chen D, Chen JX, Yan SD, Gunn-Moore FJ. Endophilin I expression is increased in the brains of Alzheimer disease patients. J Biol Chem. 2008 Feb 29;283(9):5685-91
Chen JX, Yan SD. Pathogenic role of mitochondrial amyloid-beta peptide. Expert Rev Neurother. 2007 Nov; 7(11): 1517-25.
Yao J, Taylor M, Davey F, Ren Y, Aiton J, Coote P, Fang F, Chen JX, Yan SD, Gunn-Moore FJ. Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer’s disease patients and a transgenic Alzheimer’s disease mouse model. Mol Cell Neurosci. 2007 Jun;35(2):377-82. Epub 2007 Apr 1.
Chen X, Sterio D, Ming X, Para DD, Butusova M, Tong T, Beric A. Success rate of motor evoked potentials for intraoperative neurophysiologic monitoring: effects of age, lesion location, and preoperative neurologic deficits. J Clin Neurophysiol. 2007 Jun;24(3):281-5.
Chen X, Stern D, and Yan SD. Cellular targets of amyloid beta Peptide: potential roles in neuronal stress and toxicity. Chapter 11, Neurobiology of Alzheimer’s Disease (Molucelar and cellular biology series) 3rd edition, Oxford Publications, 2007; pp227-244.
Yan SD, Chen X, and Wu H. ABAD: mitochondrial target for amyloid-induced cellular perturbation relevant to Alzheimer disease.Research Progress in Alzheimer’s Disease and Dementia. Book Chapter, Nova Science Publishers, Inc. 2006
Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G, Yan SD. Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer’s disease. FASEB J. 2005 Dec;19(14):2040-1. Epub 2005 Oct 6.
Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J. 2005 Apr;19(6):597-8. Epub 2005 Jan 21.
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 2004 Oct 13;23(20):4096-105. Epub 2004 Sep 30
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer’s disease. Science. 2004 Apr 16;304(5669):448-52.
Yan SS, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFaille J, Chess L, Stern DM, Jiang H. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med. 2003 Mar;9(3):287-93. Epub 2003 Feb 24.
Du Yan S, Zhu H, Fu J, Yan SF, Roher A, Tourtellotte WW, Rajavashisth T, Chen X, Godman GC, Stern D, Schmidt AM. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5296-301.
Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer’s disease. Nature. 1997 Oct 16;389(6652):689-95.
Chen X, Yan SD, Fu J, Herbert J. Genetic assay for multimerization of both normal and mutant transthyretin. Amyloid 1996(3): 245-251.
Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer’s disease. Nature. 1996 Aug 22;382(6593):685-91.
Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P, et al. Non-enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med. 1995 Jul;1(7):693-9.
Schon EA, Sciaco M. Palloti F, Chen X, Bonilla E. Mitochondrial DNA muitations and aging. In: Cellular Aging and Cell Death. Ed: NJ Holbrook, GR Martin, and RA Lockshin, John Wiley-Liss, Inc. 1994: 19-34.
Yan SD, Chen X, Schmidt AM, Brett J, Godman G, Zou YS, Scott CW, Caputo C, Frappier T, Smith MA, et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7787-91.
Chen X, Simonetti S, DiMauro S, Schon EA. Accumulation of mitochondrial DNA deletions in oganisms with various life spans. Bull Mol Biol Med 1993; 18: 57-66.
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.