Depending on an individual’s personal and family history, multigene panel genetic testing may be used to evaluate other breast cancer–associated genes.
Known Genetic Mutations for Increased Breast Cancer Risk:
- BRCA1 and BRCA2
- TP53 (associated with Li-Fraumeni syndrome)
- PTEN (associated with Cowden syndrome)
- CDH1 (associated with hereditary diffuse gastric cancer syndrome)
New research findings may discover other breast cancer–associated genes.
We recommend that people who have these mutations talk to a genetic counselor or doctor experienced in the care of people with hereditary cancer genetic mutations to discuss recommendations for managing the risk associated with these mutations.