Clinical Updates & Insights

Our clinical updates provide you with timely information about Memorial Sloan Kettering’s new treatment approaches, key clinical trials, and innovations in detecting and treating many cancers.

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229 Clinical Updates found
The Most Recent Staging System for Thyroid Cancer Downgrades Almost One-Third of Cases
Clinical Update
The Most Recent Staging System for Thyroid Cancer Downgrades Almost One-Third of Cases

The newest edition of the thyroid cancer staging system has increased the age at diagnosis as a prognostic factor by a decade.
cancer smart
Clinical Update
Watch-and-Wait Strategy Results in Rectal Preservation for Select Rectal Cancer Patients

A carefully monitored, multidisciplinary watch-and-wait strategy can result in excellent rectal preservation and pelvic tumor control for a large majority of select patients with rectal cancer who show a clinical complete response after neoadjuvant therapy.
Robert Young, MD
Clinical Update
Case Study: Pituitary Carcinoma Response to Immunotherapy

Treating pituitary tumors with combination immunotherapy may be an effective treatment strategy, especially for tumors that are resistant to temozolomide.
Blood Vials
Clinical Update
Circulating Tumor DNA Analysis Allows Rapid Therapy Matching in Lung Cancer

Our recent prospective study data provides support for the incorporation of plasma next-generation sequencing (NGS) assays into lung cancer practice guidelines.
Pictured: Dr. Mario Leitao, Jr. and Dr. Nadeem Abu-Rustum
Sentinel Lymph Node Algorithm Noninferior to Full Pelvic Lymphadenectomy in Advanced Endometrial Cancer

Oncologic outcomes are similar with the use of a sentinel lymph node algorithm compared to performing a full pelvic and paraaortic lymph node dissection in node-negative patients with deeply invasive endometroid endometrial carcinoma.
Nadeem Abu-Rustum, MD, FACOG, FACS
Uterine-Preserving Surgery Achieves Same Oncologic Outcomes as Hysterectomy in Early-Stage Cervical Cancer

Uterine-preserving surgery results in excellent and similar five-year disease-specific survival compared to hysterectomy in young women with stage IB1 cervical cancer.
Pictured: Martin Weiser, MD
Clinical Update
Care Bundle Reduces Surgical Site Infections in Colorectal Cancer Surgery

Our findings indicate that surgical site infections can be reduced effectively over the long term with a hospital-wide implementation of multidisciplinary best practices.
David Hyman, MD and patient
Clinical Update
MSI Status: Actionable Mutations in Advanced Endometrial Cancer

Sequencing advanced endometrial tumors with the MSK-IMPACT™ assay provides an effective method for detecting microsatellite instability (MSI) and germline cancer predisposition syndromes
Pictured: Michael Zelefsky
Clinical Update
Image-Guided RT Reduces Potential Under-Dosing in High-Risk Prostate Cancer

All radiotherapy treatments for prostate cancer should be accompanied by image-guidance of the prostate position to rule out significant setup errors in fractional delivery.
Howard Scher
Clinical Update
Profiling Prostate Tumors for MSI May Inform Better Treatment Selection

Profiling prostate cancer tumors for microsatellite instability (MSI) status with targeted next-generation sequencing can identify patients who may respond better to PD-1/PD-L1 agents.