Thirty-four-year-old Jason Mascolo put off getting the nagging pain in his leg checked out for years because he didn’t have health insurance. It wasn’t until he got a job with benefits — as a utility worker with Consolidated Edison — that he went to see a doctor. The news was not good. The doctor told him he had a tumor. “I heard that, and I knew it was bad,” remembers Jason, who’d recently gotten married. His doctor recommended specialists at Memorial Sloan Kettering Cancer Center (MSK).
A biopsy revealed that Jason had a rare cancer called a sarcoma, which had spread (metastasized) to his chest, lungs, and abdomen.
Jason’s diagnosis was very serious, but he was in the right place. MSK’s Sarcoma Center is world-renowned. Recently, MSK researchers published the two largest studies ever on the genetic analysis of sarcoma tumors. These specialized molecular tests can suggest personalized cancer treatments, which are sometimes more effective than standard chemotherapy and may have fewer side effects.
MSK Is a Destination for Sarcoma Treatment
The first step in Jason’s treatment was chemotherapy to shrink the tumor. After some treatment, a surgeon was able to remove the cancer from Jason’s leg. But the other tumors were much more stubborn, despite five different types of chemotherapy over a two-year period. By 2017, Jason and his wife were expecting a baby girl, and he had run out of options for chemotherapy.
Then Jason’s MSK medical oncologist, Mrinal Gounder, found something in the molecular testing of Jason’s tumor that suggested a promising avenue for treatment: a gene mutation that triggers the formation of many other cancerous mutations. Dr. Gounder told Jason he was likely to respond to a class of immunotherapy drugs called checkpoint inhibitors. These drugs work best against tumors with a large number of mutations, called a high tumor mutation burden (TMB).Back to top
Personalized Drug Treatment Effective Against Jason’s Rare Sarcoma Tumor
Jason received a combination of the drugs ipilimumab (Yervoy®) and nivolumab (Opdivo®) — a treatment originally developed at MSK for melanoma. MSK medical oncologist Sandra D’Angelo later led a clinical trial showing that it also could benefit some people with sarcoma. However, at the time Jason received the treatment, it was not covered by his insurance. Dr. Gounder interceded on Jason’s behalf and convinced the drug company to provide it under a program called compassionate use.
The results were dramatic. The immunotherapy worked. “Shortly after my daughter, Maeve, was born, Dr. Gounder called to tell me my tumors were shrinking,” Jason says. “He called it a miracle.” Today, Jason no longer needs any treatment and remains cancer free.Back to top
Molecular Analysis of Sarcoma Tumors Could Revolutionize Treatment
Two recent studies from MSK’s sarcoma team gave insight into how genetic evaluation of tumors can contribute to personalized medicine. The findings have the potential to make fundamental improvements to the way people with sarcoma are treated — both at MSK and beyond.
One study, co-led by MSK medical oncologist Benjamin Nacev, evaluated data from more than 2,100 patients who had molecular analysis of their tumors at MSK, using a test called MSK-IMPACT®. The other study, led by Dr. Gounder, looked at data from an additional 7,400 patients who had their tumors analyzed at other hospitals using a commercial test.
Both papers were published June 15, 2022, in Nature Communications.
Dr. Gounder’s study found that for about 10% of people with sarcoma, next-generation sequencing of tumor tissue actually led to a change in diagnosis. “Sarcoma is a difficult cancer, and it’s challenging to get an accurate diagnosis outside a specialized cancer center,” he says.
The investigators then reviewed their findings with OncoKB™, a database developed at MSK that’s used to match patients with the best personalized therapies based on the mutations found in their tumors. Utilizing OncoKB, Dr. Gounder determined that about one-third of sarcoma patients in his study had mutations that are likely to respond to targeted therapies — either approved drugs or experimental treatments. Another 4% were likely to benefit from immunotherapy because of high TMB.
“Sarcoma is a really rare disease, making up only about 1% of all solid tumors,” Dr. Gounder explains. “Based on how the cancer cells look under the microscope, as well as the molecular changes that we can detect, we know there are more than 100 subtypes.” Jason’s subtype is called perivascular epithelioid cell neoplasm (PEComa).Back to top
Helping More Patients Benefit from Personalized Medicine
“In this era of precision medicine, it’s important to look at how next-generation sequencing tests like MSK-IMPACT can benefit patients with sarcoma,” Dr. Gounder adds. “These findings suggested that those with advanced sarcoma should consider having their tumors analyzed.”
“Both of these papers are really striving to provide tools that help the sarcoma community — not just at MSK but also the national and international communities — to do our jobs better,” says Dr. Nacev, who is a fellow of the Jennifer Goodman Linn Laboratory of New Drug Development in Sarcoma and Rare Cancers. “They provide information that not only can potentially guide the development of new treatments for patients but can really help those working on the basic science side of the equation to learn more about the disease,” he adds.
Drs. Nacev and Gounder and their colleagues are sharing their findings with any doctors and scientists who want to use them. Their data will be available through the cBioPortal for Cancer Genomics, an open-source database launched by MSK computational biologists in 2008. Additionally, OncoKB — which received recognition from the U.S. Food and Drug Administration in 2021 — can be used by doctors anywhere in the world to match their patients with personalized drugs based on the molecular analysis of their tumors.Back to top
Jason Is Thankful for Reduced Side Effects and Full Recovery From Immunotherapy Treatment
Jason had a few side effects from the immunotherapy, but he didn’t feel nearly as sick as when he was getting chemotherapy. Checkpoint inhibitors often cause joint pain. In Jason’s case, this pain was successfully treated with steroids.
Jason, who is now 41 and lives in White Plains, New York, is thankful that he was able to work throughout his cancer journey. He says Con Ed was very accommodating, putting him on light duty while he was in active treatment without cutting his hours. He’s now back to his full workload and pursuing all the other things he likes to do, including playing golf and spending time with his family.
“My experience was taxing, but I’ve made it to the other end, which is good,” Jason says. “I feel grateful that I met Dr. Gounder. I also want to thank my wife, Tricia; my mother-in-law; my father-in-law; and my mother, who helped me during this part of my life.”
By using the latest molecular tools to analyze sarcoma tumors, doctors at MSK and around the world will be able to help more patients like Jason.Back to top