Meet Medical Oncologist Sandra D’Angelo
Meet Medical Oncologist Sandra D’Angelo
Sandra P. D'Angelo, MD
Medical Oncologist
Titles
Associate Attending Physician
Clinical Expertise
Sarcomas of Soft Tissue and Bone; Merkel Cell Carcinoma
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New Patient Appointments
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Dr. D'Angelo accepts the following list of insurance providers. Select your insurance provider to see more details.
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO PPO, POS, Transplant
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): HMO, PPO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO PPO, POS
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): Supplemental
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Payor Type: Commercial
In Network Coverage Type(s): POS, EPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO, DSN
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): EPO, HMO, PPO, POS
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): HMO, PPO
Payor Type: Commercial
In Network Coverage Type(s): PPO EPO
Payor Type: Commercial
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): EPO
Payor Type: Commercial
In Network Coverage Type(s): EPO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): Federal Government
Payor Type: Commercial
In Network Coverage Type(s): Supplemental
Payor Type: Commercial
In Network Coverage Type(s): PPO/OAP
Payor Type: Other
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): TBD
Payor Type: Commercial
In Network Coverage Type(s): HMO/EPO
Payor Type: Commercial
In Network Coverage Type(s): PPO, EPO
Payor Type: Commercial
In Network Coverage Type(s): State Government
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Contact and Location
- 646-888-4159 Office Phone
- Speaks English and Italian

Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offer many services, including screening, chemotherapy, and medical testing.
See all locationsAbout Me
Education
MD, SUNY Downstate College of Medicine
Residencies
Internal Medicine - New York University; Internal Medicine - Memorial Sloan Kettering Cancer Center; Chief Residency (Internal Medicine) - Memorial Sloan Kettering Cancer Center
Fellowships
Oncology - Memorial Sloan Kettering Cancer Center
Board Certifications
Internal Medicine; Medical Oncology
I am a medical oncologist specializing in the care of soft tissue sarcomas and bone sarcomas, as well as Merkel cell carcinoma. I work very closely with our multidisciplinary team of medical oncologists, surgeons, radiation oncologists, nurses, and patient support advocates to provide the best care and treatment for patients with these rare diseases. Our highly specialized team recognizes and appreciates the unique challenges that confront our patients, and we are all committed to addressing their needs. I partner with my patients and empower them while ensuring that they always get optimal care.
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In my research, I am developing innovative ways to use immunotherapy to treat these cancers. I have designed and conducted numerous clinical trials of investigational therapies (drugs in development) that use the body’s immune system to attack multiple types of sarcoma. These include trials of immune checkpoint inhibitors, which “release the brakes” on the immune system, allowing it to fight tumors. Immune checkpoint inhibitors have been shown to be effective in the treatment of specific sarcomas, such as undifferentiated pleomorphic sarcoma, angiosarcoma, and dedifferentiated liposarcoma. I have also led clinical trials studying T cells engineered to recognize a specific molecule on synovial sarcomas and myloid round cell liposarcomas.
In my translational research (research done in the laboratory to develop new ways to diagnose and treat disease), I am investigating biomarkers predictive of benefit from systemic immunotherapy in patients with sarcoma. At MSK, we are at the forefront of sarcoma immunotherapy research and have already contributed to the field in meaningful ways while improving the lives of our patients.
Awards and Honors
- R01 CA259169-01A1, FDA (2022)
- P50 CA217694 Career Enhancement Award (2020)
- Sarcoma Foundation Alliance (2018)
- Research Grant Recipient, Memorial Sloan Kettering Cancer Center Society (2015)
- Career Development Award, Conquer Cancer, the ASCO Foundation (2015)
- Alliance Scholar Award, Alliance for Clinical Trials in Oncology Foundation (2014)
- Young Investigator Award, Conquer Cancer, the ASCO Foundation (2011)
Colleagues
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
Clinical Trials
- Clinical Trials Investigated by Dr. D'Angelo
- A Phase I/II Study of INCMGA00012 Immunotherapy with Gemcitabine and Docetaxel in People with Advanced Soft Tissue Sarcoma
- A Phase II Study of ADP-A2M4 Gene Therapy in People with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
- A Phase II Study of Palbociclib and INCMGA00012 in People with Advanced Dedifferentiated Liposarcoma
- A Study of Envafolimab Alone and in Combination with Ipilimumab Immunotherapy in People with Undifferentiated Pleomorphic Sarcoma or Myxofibrosarcoma
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- Clinical Trials Co-Investigated by Dr. D'Angelo
- A Phase I Study of FHD-609 in People with Advanced Synovial Sarcoma
- A Phase I/II Study of TTI-621 Combined with Doxorubicin in People with Advanced Soft Tissue Sarcoma
- A Phase II Study of KRT-232 in Merkel Cell Carcinoma That Has Not Responded to Immunotherapy
- A Phase II Study of Pembrolizumab Immunotherapy plus Local Chemotherapy using Isolated Limb Infusion for Patients with Advanced Sarcoma in the Arm or Leg
- A Phase II Study of Radiation Therapy with or without Avelumab in People with Advanced Merkel Cell Carcinoma
- A Phase III Study of Avelumab Immunotherapy versus Placebo in Patients with Merkel Cell Carcinoma that Spread to the Lymph Nodes
- A Pilot Study of Lenvatinib and Pembrolizumab Immunotherapy in People with Advanced Soft Tissue Sarcoma

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Search clinical trialsResearch and Publications
D’Angelo SP, Melchiori L, Merchant MS, Bernstein D, Glod J, Kaplan R, Grupp S, Tap WD, Chagin K, Binder GK, Basu S, Lowther DE, Wang R, Bath N, Tipping A, Betts G, Ramachandran I, Navenot JM, Zhang H, Wells DK, Van Winkle E, Kari G, Trivedi T, Holdich T, Pandite L, Amado R, Mackall CL. Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259T Cells in Synovial Sarcoma. Cancer Discov. 2018 Aug;8(8):944-957. doi: 10.1158/2159-8290.CD-17-1417. Epub 2018 Jun 11. PMID: 29891538; PMCID: PMC8092079.
D’Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H. Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol. 2018 Mar;19(3):416-426. doi: 10.1016/S1470-2045(18)30006-8. Epub 2018 Jan 19. PMID: 29370992; PMCID: PMC6126546.
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D’Angelo SP, Richards AL, Conley AP, Woo HJ, Dickson MA, Gounder M, Kelly C, Keohan ML, Movva S, Thornton K, Rosenbaum E, Chi P, Nacev B, Chan JE, Slotkin EK, Kiesler H, Adamson T, Ling L, Rao P, Patel S, Livingston JA, Singer S, Agaram NP, Antonescu CR, Koff A, Erinjeri JP, Hwang S, Qin LX, Donoghue MTA, Tap WD. Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma. Nat Commun. 2022 Jun 16;13(1):3477. doi: 10.1038/s41467-022-30874-8. PMID: 35710741; PMCID: PMC9203519.
D’Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P. First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study. J Immunother Cancer. 2021 Jul;9(7):e002646. doi: 10.1136/jitc-2021-002646. PMID: 34301810; PMCID: PMC8311489.
Rosenbaum E, Antonescu CR, Smith S, Bradic M, Kashani D, Richards AL, Donoghue M, Kelly CM, Nacev B, Chan JE, Chi P, Dickson MA, Keohan ML, Gounder MM, Movva S, Avutu V, Thornton K, Zehir A, Bowman AS, Singer S, Tap W, D’Angelo S. Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single center. J Immunother Cancer. 2022 Apr;10(4):e004149. doi: 10.1136/jitc-2021-004149. PMID: 35365586; PMCID: PMC8977792.
Visit PubMed for a full listing of Dr. D'Angelo’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
See all on PubMedPatient Reviews
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Sandra P. D'Angelo discloses the following relationships and financial interests:
-
Aadi Bioscience, Inc.
Provision of Services -
Adaptimmune
Provision of Services -
GI Innovation Inc.
Provision of Services
-
GlaxoSmithKline
Provision of Services -
Pfizer, Inc.
Provision of Services -
Servier
Provision of Services
If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].