Osteosarcoma (Bone Cancer) Clinical Trials

MSK Kids has multiple clinical trials assessing new therapies for osteosarcoma. One of them is looking at a treatment that boosts the power of the immune system against osteosarcoma that has spread. This immunotherapy has helped children with a cancer called neuroblastoma. It is our hope that it can benefit children with osteosarcoma, too.

Your child’s care team will let you know if your child can participate in a clinical trial. The decision to enroll is entirely voluntary. The study team will explain the benefits and risks of the study to you so you can make an informed decision.

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6 Clinical Trials found
A Phase 1/2 Study of Afamitresgene Autoleucel SPEAR T Cell Therapy in Children and Young Adults With Solid Tumors
Researchers are assessing a new type of therapy in young people with solid tumors that keep growing even after treatment. The therapy is called afamitresgene autoleucel. The people in this study have synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), neuroblastoma, or osteosarcoma. In addition, they have tested positive for the HLA-A*02 gene and their cancers make a protein called MAGE-A4. This protein plays a role in cancer growth.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 1/2 Study of CBL0137 to Treat Advanced Solid Tumors in Children and Young Adults
Researchers in this study are seeking the best dose of CBL0137 in people with solid tumors. They also want to see how well it works against certain cancers.
New York City
A Phase 2-3 Study Assessing the Addition of Cabozantinib to Chemotherapy in People With Newly Diagnosed Osteosarcoma
Researchers want to see if adding cabozantinib to standard chemotherapy works better than chemotherapy alone for osteosarcoma. The people in this study include children, adolescents, and young adults with osteosarcoma that has not yet been treated.
New York City
A Phase III Study Comparing Two Surgery Methods to Treat Cancer in the Lung in Patients with Bone Cancer
The purpose of this study is to compare two different approaches to surgery for children and adults with osteosarcoma (bone cancer) that has spread (metastasized) to the lungs. Participants will be randomly assigned to one of two techniques:
New York City
A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
Expanded Access to L-MTP-PE for the Treatment of Osteosarcoma
This protocol will provide expanded access to treatment with the investigational drug L-MTP-PE for people with osteosarcoma. L-MTP-PE works by activating certain types of white blood cells, and these active white blood cells help the immune system to kill cancer cells. L-MTP-PE is given intravenously (by vein).
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau