MDA-MB-231 TGL: Human Breast Adenocarcinoma Cell Line

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Description  

MDA-MB-231 TGL is a parental breast adenocarcinoma cell line and a triple negative breast cancer (TNBC) cell line. It is also known as MDA231-TGL. 

This cell line is part of a panel of human breast cancer cell lines selected to metastasize to specific organs.   

Source 

This cell line was established from a 51-year-old female of Caucasian ethnicity and was derived from a metastatic site of pleural effusion.   

Lead Inventor 

Joan Massagué, PhD, Director, Sloan Kettering Institute, and Laboratory Head, Cancer Biology & Genetics Program, MSK   

This cell line is jointly owned with MD Anderson and is available for licensing through an interinstitutional agreement. 

Key References 

  • Minn A et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050) 518-524. (PubMed ID: 16049480
  • Boire A et al. (2017) Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.Cell, 168(6), 1101-1113.e13. (PubMed ID: 28283064

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Stage of Development

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