Adriana Haimovitz-Friedman, PhD

Attending Radiation Biologist
Adriana Haimovitz-Friedman, PhD

Office Phone

646-888-2172

Office Fax

646-422-0281

Email

[email protected]

Publications

Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Modulation of the Apoptotic Response: Potential for Improving the Outcome in Clinical Radiotherapy. Seminars in Radiation Oncology, 1996; 6:273-283.

Haimovitz-Friedman A. Radiation-induced Signal Transduction and Stress Response. In: Radiation Research special issue commemorating the discovery of radium and polonium by Marie Curie in 1898. Radiat. Res. 1998; 150: S102-S108.

Fuks Z, Persaud R, Alfieri A, McLoughlin M, Schwartz J L, Cordon-Cardo C, Seddon AP, Haimovitz-Friedman A. Basic Fibroblast Factor Protects Endothelial Cells Against Radiation-Induced Programmed Cell Death in vitro and in vivo. Cancer Res.1994; 54: 2582-2590.

Haimovitz-Friedman A, Balaban N, McLaughlin M, Ehleiter D, Michaeli J, Fuks Z. Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells Against Radiation-Induced Apoptosis. Cancer Res. 1994; 54: 2591-2597.

Haimovitz-Friedman A, Kan C-C, Ehleiter D, Persaud R, McLaughlin M, Fuks Z. Ionizing Radiation Acts Directly on Cellular Membranes to Generate Ceramide and Initiate Apoptosis. J. Exp. Med. 1994; 180:525-535.

Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Environmental stresses signal apoptosis through a ceramide-initiated SAPK/JNK-mediated cascade. Nature, 1996; 380:75-79.

Liao W C*, Haimovitz-Friedman A*, Persaud R, McLoughlin M, Ehleiter D, Zhang N, Gatei M, Lavin M, Kolesnick RN, Fuks Z. ATM inhibits DNA damage-induced apoptosis via ceramide synthase. J. Biol. Chem. 1999; 274: 17908-17917.
*Both authors contributed equally to this publication.

Garzotto M, Haimovitz-Friedman A, White-Jones M, Liao W-C, Huryk R, Heston DW, Cordon-Cardo C, Kolesnick RN, Fuks Z. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Can. Res., 1999, 59: 5194-520.

Paris F, Kang A, Capodieci P, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Fuks Z, Kolesnick RN. Endothelial Apoptosis is the Primary Lesion Initiating Radiation Damage to the Intestines. Science, 2001 July 293: 293-297.

Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick RN. Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med., 8 : 901-902, 2002.

Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to low-dose radiotherapy regulated by endothelial cell apoptosis. Science, 300: 1155-1159, 2003.

Truman J-P, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem 2005, 280: 23262-23272.

Chang H-J, Maj J, Paris FE, Xing HR, Zhang J, Truman J-P, Cordon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med., 2005, 11: 484-490.

Rotolo J, Maj J, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng E, Kolesnick R, Fuks Z. Bax and bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys., 2008, 70: 321-650.

Truman J-P, Rotenberg SA, Kang J-H, Lerman G, Fuks Z, Kolesnick R, and Haimovitz-Friedman A. PKCα activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biology and Therapy 2009: 8(1): 54-63.

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Adriana Haimovitz-Friedman discloses the following relationships and financial interests:

  • Ceramedix
    Intellectual Property Rights

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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