Jonathan Villena-Vargas

Research Fellow

Jonathan Villena-Vargas

Research Fellow

Awards and Scholarships

  • NIH T-32 Research Fellowship
  • The Society of Thoracic Surgery “Looking to the Future” Resident Scholarship

Current Employment

Surgical Resident, Beth Israel Medical Center, New York, NY

Publications

Manuscripts

  • Kadota K, Eguchi T, Villena-Vargas J, Woo KM, Sima CS, Jones DR, Travis WD, Adusumilli PS. Nuclear Estrogen Receptor-α Expression Is an Independent Predictor of Recurrence in pT1aN0 Lung Adenocarcinomas, and Correlates with Regulatory T-Cell Infiltration. Oncotarget. 2015 (in press)
  • Kadota K, Buitrago DH, Lee MC, Villena-Vargas J, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumoral CD10 Expression Correlates with High-Grade Histology and Increases Risk of Recurrence in Patients with Stage I Lung Adenocarcinoma. Lung Cancer. 2015 Jun 15. pii: S0169-5002(15)00288-3. (PMC4156131) PMID: 26141216.
  • Kadota K, Yeh Y-C, Villena-Vargas J, Cherkassky L, Drill EN, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumor Budding Correlates with Protumor Immune Microenvironment and is an Independent Prognostic Factor for Recurrence of Stage I Lung Adenocarcinoma. CHEST. 2015 Apr 2. [Epub ahead of print] PMID: 25836013.
  • Kadota K, Villena-Vargas J, Nitadori JI, Sima CS, Jones DR, Travis WD, Adusumilli PS. Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. Ann Surg Oncol. 2015 Jan 22. [Epub ahead of print] PMID: 25608772.
  • Adusumilli PS, Cherkassky L, Villena-Vargas J, Colovos C, Servais E, Plotkin J, Jones DR, Sadelain M. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med. 2014 Nov 5;6(261):261ra151. (PMC4373413) PMID: 25378643.
  • de Biasi AR, Villena-Vargas J, Adusumilli PS. Cisplatin-Induced Immunomodulation: A Review of Preclinical and Clinical Evidence. Clin Cancer Res. 2014 Nov 1;20(21):5384-91. (PMC4216745) PMID: 25204552.
  • Kadota K, Villena-Vargas J, Yoshizawa A, Motoi N, Sima CS, Riely GJ, Rusch VW, Adusumilli PS, Travis WD. Prognostic Significance of Adenocarcinoma in situ, Minimally Invasive Adenocarcinoma, and Nonmucinous Lepidic Predominant Invasive Adenocarcinoma of the Lung in Patients with Stage I Disease. Am J Surg Pathol. 2014 Apr;38(4):448-60. PMID: 24472852.
  • Kachala S, Bograd A, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, Chou J, Sima CS, Vertes E, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin overexpression is a marker of tumor aggressiveness and its associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. Clin Cancer Res. 2014 Feb 15;20(4):1020-8. PMID: 24334761; PMCID: PMC3944669.
  • Villena-Vargas J, Adusumilli PS. Mesothelin-targeted immunotherapies for malignant pleural mesothelioma. Ann Cardiothorac Surg. 2012 Nov;1(4): 466-471.
  • Colovos C, Villena-Vargas J, Adusumilli PS. Safety and stability of retrovirally transduced chimeric antigen receptor T cells. Immunotherapy. 2012 Sep;4(9):899-902. PMID: 23046233.

Abstracts/Presentations

  • Cherkassky L, Morello A, Villena-Vargas J, Mayor M, Jones DR, Sadelain M, Adusumilli PS. Genetic-Engineering Strategies to Enhance CAR T-Cell Therapy Efficacy against PD-L1 Expressing Lung Adenocarcinoma and Mesothelioma. International Association for the Study of Lung Cancer (IASLC) 16th World Conference on Lung Cancer. September 6-9, 2015; Denver, CO.
  • Bograd AJ, Villena-Vargas J, Colovos C, Kachala S, Jones DR, Sadelain M, Adusumilli PS. Beneficial Role of Antigen Commensalism in Mesothelin-Targeted T-cell Therapy for Lung Adenocarcinoma. 18th Annual C. Walton Lillehei Resident Forum. April 27, 2015; New York, NY.
  • Villena-Vargas J, Cherkassky L, Colovos C, Servais E, Rodriguez L, Rusch VW, Sadelain M, Adusumilli PS. Critical role of CD28 costimulation in tumor-targeted T -cell therapy clinical trial for pleural malignancies. 15th World Conference on Lung Cancer, 2013 October 27-30; Sydney, Australia. (Oral Presentation)
  • Villena-Vargas J, Rodriguez L, Moroz M, Cherkassky L, Rusch VW, Sadelain M, Ponomarev V, Adusumilli PS. T-cell imaging to noninvasively monitor adoptive T-cell therapy for thoracic malignancies. 15th World Conference on Lung Cancer, 2013 October 27-30; Sydney, Australia. (Oral Presentation)
  • Villena-Vargas J, Kadota K, Nitadori J, Sima CS, Krug L, Travis WD, Rusch VW, Adusumilli PS. CD10 expression is an independent prognostic factor among all histological types of malignant pleural mesothelioma. International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, October 27-30, 2013, Sydney, Australia.
  • Xu C, Villena-Vargas J, Sadelain M, Adusumilli PS. Induction of T-regs in chimeric antigen receptor (CAR)-transduced T cells: Role of costimulation and tumor-secreted TFG-p. 36th Annual Memorial Sloan-Kettering Cancer Center Medical Student Summer Fellowship Program Poster Presentation. August 1, 2013; New York, NY. (Poster)