The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically. The biologically significant DNA damage caused by ionizing radiation and a number of cytotoxic drugs requires double-strand break repair for survival. We have largely focused on the role of double-strand break repair and homologous recombination in particular.
Simon N. Powell, MD, PhD
Research FocusMolecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.
- PhD, MD, University of London
- Bindra RS, Goglia AG, Jasin M, Powell SN. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res. 2013 Jun 1;41(11):e115. doi: 10.1093/nar/gkt255. Epub 2013 Apr 12.
- Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. PubMed