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Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.

… The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design

Alban Ordureau explores molecular signaling pathways that regulate cellular homeostasis, with a focus on the ubiquitin and autophagy systems.

… My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end, we combine cell biological, genome engineering (CRISPR), and biochemical approaches to provide new

The Minn Lab investigates how cancers evolve under chronic inflammation and persistent immune pressure to acquire resistance to immunotherapies, with the goal of developing innovative therapies to restore anti-tumor immunity.

… In the Minn Lab, we interrogate the intersection of chronic inflammation and interferon signalling, virus mimicry pathways, and immune checkpoint resistance in tumor cells — integrating cellular, molecular and translational approaches. Our goal is to convert mechanistic insights into new therapeutic

The Hite laboratory studies the mechanisms of ion and metabolite transport and the maintenance of genomic integrity.

… Our research group has two primary focuses. One part of the lab focuses on determining the mechanisms of intracellular ion and metabolite transport, while the second studies protein nucleic acid interactions that are critical for maintaining genomic integrity. We study these fundamental processes using

Molecular biologist John Maciejowski studies the causes of complex chromosome rearrangements and the patterns of hypermutation that shape cancer genomes.

… The nuclear envelope is a regulated membrane barrier that separates the nucleus from the cytosol in eukaryotes. Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures

The Vardhana Lab studies how nutrient availability, uptake and metabolism regulates host immune responses during cancer development and immunotherapy.

… The Vardhana lab explores how metabolites regulate immune cell homeostasis, particularly within tumors.  We use a combination of traditional immunology, synthetic biology, metabolomics, and bioinformatics to answer fundamental biological questions about the regulation of immune responses with the goal

Physician-scientist Babak Mehrara studies the regulation of lymphatic regeneration after surgery and development of lymphedema.

… Our research group focuses on the lymphatic system in three different pathological settings: lymphedema, obesity, and cancer. Chronic lymphedema is a morbid disease condition without any cure. Our first goal is to uncover the pathology behind development and progression of cancer-related secondary lymphedema

The Widman Lab within the Digital Oncology Program at MSKCC is using machine learning and genomics to engineer the next-generation of ultrasensitive, highly scalable liquid biopsies for early cancer detection, treatment monitoring, and detection of minimal residual disease (MRD) after surgery for early-stage cancer.

… The Widman lab within the Digital Oncology Program at MSKCC is using machine learning and genomics to engineer the next-generation of ultrasensitive, highly scalable liquid biopsies for early cancer detection, treatment monitoring, and detection of minimal residual disease (MRD) after surgery for early-stage

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

… The Schultz lab focuses on identifying the genomic alterations that underlie different types of cancer. By applying existing and novel computational methods to large scale cancer genomics data sets, the lab aims to better understand the complex mechanisms at the gene and at the pathway level that drive

Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.

… Physician-scientist Charles M. Rudin, Chief of the Thoracic Oncology Service, leads research that focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models including patient-derived xenografts. These studies are integrated with early phase clinical trials