Search

Molecular biologist Scott Keeney investigates mechanisms of the initiation of meiotic recombination.

… The long-range objectives of our research are to understand the mechanism of meiotic recombination and to determine how this process is coordinated with other events of meiotic prophase. Several projects in the lab focus on Spo11 (the protein that makes the DNA double-strand breaks (DSBs) that initiate

Physician-scientist Aimee Crago studies mechanisms by which common genomic events drive initiation and progression of soft tissue tumors.

… The rarity of soft tissue sarcomas has historically made the definition of genomic drivers of their initiation and progression difficult.  Through copy number, whole exome and transcriptome analyses, however, common events associated with these lesions have recently been defined.  The focus of our laboratory

The Osorio Lab studies the mechanisms of antibody-mediated immunity, with a focus on myeloid cell reprograming to advance cancer immunotherapies.

… The Osorio lab investigates the mechanisms underlying antibody-mediated immunity, and how we can leverage these insights to develop durable and effective antibody-based immunotherapies. Our research focuses on harnessing the untapped potential of the innate immune system – particularly the myeloid compartment

We take real-world data, clean it and use it to discover new predictive biomarkers to guide cancer management (often with AI), and then implement these findings in clinical practice.

… AI and real-world data are alluring tools, which may transform the practice of oncology. But the integration and application of these tools to cancer research and clinical care has to improve at every step before they can meaningfully improve the lives of patients.  To develop useful biomarkers, we need

The Aviram Lab investigates the molecular mechanisms that protect microorganisms from their own pathogenic invaders.

… Like any other organism, bacteria are constantly exposed to pathogenic threats, such as viruses and plasmids. The Aviram Lab is interested in understanding how bacterial cells protect themselves from invaders, focusing particularly on the CRISPR-Cas adaptive immune system. CRISPR-Cas systems have a remarkable

The Pillarsetty Laboratory develops bioactive radiopharmaceuticals and fluorophores for molecular characterization and targeted treatment of cancer.

… Targeted Theranostics Laboratory Molecularly targeted therapy modulates a dysregulated target(s) and/or biologic pathway(s) that provides survival advantage for cancer cells. This targeting enables achieve selective destruction of cancer cells while minimizing harm to normal cells. We work on the development

Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.

… The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells. Michael G. Kharas, PhD Professor PhD, University of California Irvine Achievements Leukemia and Lymphoma Society Career Development Award (2017) Alex Lemonade Stand Foundation ‘A’ Award (2016) American

Physician-scientist Nai-Kong Cheung focuses on engineering antibodies and immune cells to treat both solid tumors and liquid tumors in children.

… My lab focuses on engineering antibodies and immune cells to treat both solid tumors and liquid tumors in children. Nai-Kong V. Cheung, MD, PhD Enid A. Haupt Chair in Pediatric Oncology, Pediatrics Professor MD, PhD (Immunology), Harvard Medical School Email [email protected] Laboratory phone 646-888

Physician-scientist Christopher A. Klebanoff studies T cell immunobiology with an emphasis on adoptive T cell immunotherapy for the treatment of solid malignancies.

… A form of cancer immunotherapy termed adoptive T cell transfer (ACT), in which a patient’s own T cells are engineered to recognize and attack cancer cells, can induce durable complete remissions in patients with advanced hematologic malignancies. By contrast, a similar approach has thus far failed to

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

… Andrew Intlekofer is an Assistant Member in the Human Oncology and Pathogenesis Program and an Attending Physician on the Lymphoma Service in the Department of Medicine. Dr. Intlekofer’s research investigates how deregulated metabolic pathways contribute to cancer development and how metabolic enzymes