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Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.

… The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and

New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

… We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate

Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.

… The Grimm lab in the Molecular Pharmacology Program focuses on the development of novel and innovative approaches for cancer diagnostics and therapy. These approaches evaluate underlying biology and utilize nanotechnology, chemistry and physics interrogated with modern imaging methods. The lab focuses

Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung and pancreatic cancers.

… The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated

The Maura Lab is an energetic, highly collaborative, in-person team that combines clinical, computational, and molecular biology—leveraging bulk and single-cell genomics and close MSKCC clinical partnerships—to uncover genomic drivers of lymphoproliferative disorders and translate them into earlier detection and more personalized treatments.

… The Maura Lab integrates clinical, computational, and molecular biology to understand lymphoproliferative disorders. In particular, we identify genomic and immune drivers for initiation, progression, and treatment response. Using bulk and single-cell sequencing approaches, we develop strategies for early

Cancer biologist Andrea Ventura studies DNA structural rearrangements and non-coding RNAs in cancer and development.

… We use a combination of in vivo, in vitro, biochemical, and computational approaches to investigate various aspects of human cancer and development. Three broad biological domains we are currently exploring include extrachromosomal circular DNAs (ecDNAs), chromosomal rearrangements, and non-coding RNAs

Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.

… The Massagué lab investigates metastasis stem cells and their stromal niches throughout the metastatic cascade, with a growing interest in the dormant phase of metastasis. We are defining the phenotypic plasticity and evolution of metastatic cell populations from dormancy to outbreak, identifying drug

The Li lab studies the brain-immune circuits that regulate systemic and brain immunity.

… The Li Lab studies how brain circuits control immunity. Precisely calibrated inflammation is essential for organismal health. The central nervous system continuously monitors internal state and, through hard-wired pathways, can rapidly tune immune function. Our work centers on a brain–immune axis capable

The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease.

… The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease. Projects:  Elucidate the behaviors of stem cells and their niches during lung development, regeneration and disease