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Molecular biologist John Maciejowski studies the causes of complex chromosome rearrangements and the patterns of hypermutation that shape cancer genomes.

… The nuclear envelope is a regulated membrane barrier that separates the nucleus from the cytosol in eukaryotes. Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures

The Vardhana Lab studies how nutrient availability, uptake and metabolism regulates host immune responses during cancer development and immunotherapy.

… The Vardhana lab explores how metabolites regulate immune cell homeostasis, particularly within tumors.  We use a combination of traditional immunology, synthetic biology, metabolomics, and bioinformatics to answer fundamental biological questions about the regulation of immune responses with the goal

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

… The focus of the Fagin lab is to understand the pathogenesis and the biology of thyroid cancers at single cell resolution with the goal of identifying new mechanism-based therapies.  His group has been instrumental in characterizing somatic genetic changes associated with tumor initiation and progression

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.

… The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches

The Brown Lab studies how the tissue environment shapes immune cell fate and function during early life immune development, inflammation, and cancer.

… At the Brown Lab, we’re studying how signals from the tissue environment shape the fate and function of immune cells and the mechanisms by which the immune system reciprocally regulates tissue homeostasis and host immunity. At the heart of an immune response are dendritic cells, sentinels of the immune

Molecular biologist Thomas Kelly studies regulatory mechanisms that control DNA replication during the cell cycle of eukaryotic cells.

… My long-term interest is to understand how the cellular genome is duplicated during the cell cycle. In the course of growth and division, eukaryotic cells duplicate their genomes with remarkable fidelity. The precision of this process depends in large measure upon stringent regulatory mechanisms that

Computational biologist Ruslan Soldatov develops computational methods to study cell fate decisions and somatic evolution in normal tissues and cancer.

… The Soldatov Lab aims to characterize the mechanisms of cell fate decisions that coordinate tissue function and quantify how distortions of these mechanisms shape the course of cancer evolution. We are broadly interested in using a large-scale data science approach to study questions related to the organization

Molecular biologist Prasad Jallepalli studies the mechanisms that ensure accurate chromosome transmission in human cells.

… Our laboratory is interested in how human cells accurately duplicate and transmit their chromosomes during each round of division. Prasad Jallepalli, MD, PhD Member Professor MD, PhD, Johns Hopkins University School of Medicine Achievements Phi Beta Kappa, Harvard University (1992) M.D./Ph.D. Fellow,

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

… The Schultz lab focuses on identifying the genomic alterations that underlie different types of cancer. By applying existing and novel computational methods to large scale cancer genomics data sets, the lab aims to better understand the complex mechanisms at the gene and at the pathway level that drive

Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.

… The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in cancer and autoimmune disease. The patrolling T cells constantly scan host tissues to eliminate infected or malignant cells. Failure to recognize such cells leads to pathogen evasion or cancer. Whereas mis-recognizing