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Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.

… Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma. Liang Deng, MD

Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.

… The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger

Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.

… Dr. Sawyers is an HHMI Investigator searching for molecularly targeted approaches to treat cancer. He has identified cell signaling components critical to the growth of cancer cells in chronic myeloid leukemia, prostate and other cancers, resulting in the development of multiple FDA-approved inhibitors

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.

… The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand how different cell types are made, we need a tool to observe cells’ previous and current states, as well

Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.

… I am a physician-scientist who focuses on the development of new multi-modal imaging approaches for specific applications, such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences. Vladimir Ponomarev, MD, PhD Office phone 646-888-2213

The Greenbaum lab utilizes techniques from statistical physics, information theory, and evolutionary biology to better understand the role of self/non-self discrimination in tumor evolution, model response to immunotherapies, and quantify drivers of virus and cancer evolution.

… A main goal in the Greenbaum lab is to quantify how the immune system is activated and how it impacts tumor evolution. A particular focus in the lab is the role of repetitive elements in the genome, which mimic viral features and, just like viruses, evolve to escape immune surveillance. Dr. Greenbaum

Computational biologist Quaid Morris uses artificial intelligence techniques and develops machine learning algorithms to study gene regulation, cancer evolution, clinical informatics, and other topics in systems biology.

… Our lab uses machine learning and artificial intelligence to do biomedical research, focusing on cancer evolution, gene regulation, clinical informatics, and gene function prediction. A key interest is the role of RNA-binding proteins (RBPs) in post-transcriptional regulation. We focus on developing

Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.

… Alan Hanash is an Associate Member of Memorial Sloan Kettering and an Attending Physician on the Adult Bone Marrow Transplant Service in the Department of Medicine. Dr. Hanash’s research focuses on the immunology of hematopoietic transplantation and immune-mediated mechanisms of tissue damage and regeneration

Medical physicist John Humm focuses on noninvasive imaging of the tumor microenvironment using nuclear imaging methods.

… I am head of the nuclear medicine physics section, which supports research in PET/CT, targeted therapies, and molecular imaging. As both a medical and biophysicist, I investigate nuclear imaging methodologies to define tumor targets in terms of their metabolic and microenvironmental properties. I have

Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.

… We combine computation and experiment to investigate how cells interact with each other to produce complex cell group behaviors. Joao Xavier, PhD Member, Computational & Systems Biology Program Professor PhD, Universidade Nova de Lisboa Achievements Director's New Innovator Award, National Institutes